Specificity of bovine heart protein kinase for the Δ‐stereoisomer of the metal—ATP complex
Specificity of bovine heart protein kinase for the Δ‐stereoisomer of the metal—ATP complex
复制标题
牛心蛋白激酶对金属-ATP复合物Δ-立体异构体的特异性
DOI：
10.1016/0014-5793(79)81342-3
复制
发表时间：
1979
期刊：
影响因子：
3.5
通讯作者：
E. Kaiser
中科院分区：
文献类型：
--
作者：
J. Granot;A. Mildvan;E. M. Brown;H. Kondo;H. N. Bramson;E. Kaiser
studies that the catalytic subunit of bovine heart protein kinase tight& binds 2 divalent cations only in the presence of~~ c~ eotjdes such as ATP [I] _ The data were~~ er~ re~ ed to indicate that 1 of the 2 divafent cations interacts solely with the enzyme-bound ATP forming the active ternary enzyme-ATP-M” complex. As determined by NMlR, the other, somewhat less tightly-bound divalent cation, bridges the enzyme to the trip~~ osph~ t~ chain of the metal-ATP complex,. forming ah~~~ yi~ ll~ bjted quaternary enzyme-BTP-M2” complex [2 1.
