Elevated NLR May Be a Feature of Pediatric Brain Cancer Patients
Elevated NLR May Be a Feature of Pediatric Brain Cancer Patients
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DOI：
10.3389/fonc.2019.00327
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发表时间：
2019-04-30
影响因子：
4.7
通讯作者：
Mehrian-Shai, Ruty
中科院分区：
文献类型：
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作者：
Yalon, Michal;Toren, Amos;Mehrian-Shai, Ruty
儿童脑肿瘤是最常见的实体瘤类型，也是儿童癌症相关死亡的主要原因。免疫系统在癌症发病机制和对免疫疗法治疗的应答中起重要作用。T淋巴细胞是免疫系统对癌细胞反应的关键因素，并且与不同癌症的预后相关。另一方面，中性粒细胞分泌促血管生成和抗凋亡因子，增强肿瘤细胞生长和发展成转移的能力。我们对在达纳儿童医院和舍巴医疗中心住院的120名儿童脑癌患者和171名择期儿科患者进行了回顾性研究。从常规术前血液检查中收集有关年龄、性别、治疗、淋巴细胞、中性粒细胞和单核细胞计数的数据。计算中性粒细胞与淋巴细胞比率（NLR）和淋巴细胞与单核细胞比率（LMR），并通过配对T检验确定显著性。p < 0.05被认为是统计学显著的。NLR在儿童脑癌患者中显著更高。儿童脑癌患者的高NLR是低淋巴细胞和高中性粒细胞组合的结果。这两种因素都可以在癌症的发展和传播中发挥作用，也可以对治疗做出反应。
Pediatric brain tumors are the most common solid tumor type and the leading cause of cancer-related death in children. The immune system plays an important role in cancer pathogenesis and in the response to immunotherapy treatments. T lymphocytes are key elements for the response of the immune system to cancer cells and have been associated with prognosis of different cancers. Neutrophils on the other hand, which secrete pro-angiogenic and anti-apoptotic factors, enhance the ability of tumor cells to grow and develop into metastases. We conducted a retrospective study of 120 pediatric brain cancer patients and 171 elective pediatric patients hospitalized in Dana Children's Hospital and Sheba Medical Center. Data on age, sex, treatment, lymphocyte, neutrophil, and monocyte count were collected from routinely performed preoperative blood tests. Neutrophil-to-lymphocyte ratio (NLR), and the lymphocyte-to-monocyte ratio (LMR) were calculated and significance was determined by paired T test. p < 0.05 was considered as statistically significant. NLR was significantly higher in the pediatric brain cancer patients. The high NLR in pediatric brain cancer patients is the result of a combination of low lymphocytes and high neutrophils. Both of these factors can have a role in cancer development and propagation and also in response to therapy.