Updated National Birth Prevalence Estimates for Selected Birth Defects in the United States, 2004-2006
Updated National Birth Prevalence Estimates for Selected Birth Defects in the United States, 2004-2006
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DOI：
10.1002/bdra.20735
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发表时间：
2010-12-01
影响因子：
--
通讯作者：
Correa, Adolfo
中科院分区：
文献类型：
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作者：
Parker, Samantha E.;Mai, Cara T.;Correa, Adolfo
背景：国家出生缺陷预防网络收集各州特定的出生缺陷监测数据，用于每年发布患病率估计和合作研究项目。2006年，从1999年到2001年的21个出生缺陷的数据被作为全国出生流行率估计数提供。本报告的目的是利用2004年至2006年的数据更新这些估计数字。方法：采用11个主动病例发现方案、6个有病例确认的被动病例发现方案和7个无病例确认的被动方案的人群资料进行分析。计算了21个出生缺陷的合并出生患病率估计，按病例确证方法分层。根据孕妇种族/民族和孕妇年龄(仅13三体、18三体和唐氏综合症)调整后的全国患病率估计数是使用来自14个项目的数据确定的。对于五种特定缺陷，还评估了妊娠结局对患病率估计的影响。结果：全国出生缺陷患病率估计范围从普通干的每万活产0.72人到唐氏综合症的每万活产14.47人。按监测系统类型分层显示，积极项目的无脑儿、无眼症/小眼球、唇裂伴或不伴腭裂、上肢畸形和18三体的发生率较高。无脑儿、13三体和18三体的出生患病率也因纳入选择性终止而有很大差异。结论：在美国，需要对出生缺陷患病率进行准确和及时的全国性估计，以监测趋势、评估预防工作、确定服务规划和了解因出生缺陷造成的疾病负担。出生缺陷研究(A部分)88：1008-1016,2010。(C)2010年Wiley-Liss公司
BACKGROUND: The National Birth Defects Prevention Network collects state-specific birth defects surveillance data for annual publication of prevalence estimates and collaborative research projects. In 2006, data for 21 birth defects from 1999 through 2001 were presented as national birth prevalence estimates. The purpose of this report was to update these estimates using data from 2004 through 2006. METHODS: Population-based data from 11 active case-finding programs, 6 passive case-finding programs with case confirmation, and 7 passive programs without case confirmation were used in this analysis. Pooled birth prevalence estimates for 21 birth defects, stratified by case ascertainment approach, were calculated. National prevalence estimates, adjusted for maternal race/ethnicity and maternal age (trisomy 13, trisomy 18, and Down syndrome only) were determined using data from 14 programs. The impact of pregnancy outcomes on prevalence estimates was also assessed for five specific defects. RESULTS: National birth defects prevalence estimates ranged from 0.72 per 10,000 live births for common truncus to 14.47 per 10,000 live births for Down syndrome. Stratification by type of surveillance system showed that active programs had a higher prevalence of anencephaly, anophthalmia/microphthalmia, cleft lip with or without cleft palate, reduction defect of upper limbs, and trisomy 18. The birth prevalence of anencephaly, trisomy 13, and trisomy 18 also varied substantially with inclusion of elective terminations. CONCLUSION: Accurate and timely national estimates of the prevalence of birth defects are needed for monitoring trends, assessing prevention efforts, determining service planning, and understanding the burden of disease due to birth defects in the United States. Birth Defects Research (Part A) 88: 1008-1016, 2010. (C) 2010 Wiley-Liss, Inc.