Patterns of HIV/SIV Prevention and Control by Passive Antibody Immunization.
Patterns of HIV/SIV Prevention and Control by Passive Antibody Immunization.
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DOI：
10.3389/fmicb.2016.01739
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发表时间：
2016
影响因子：
5.2
通讯作者：
Matano T
中科院分区：
文献类型：
--
作者：
Yamamoto H;Matano T
中和抗体（NAb）反应是控制人类免疫缺陷病毒（HIV）感染的有前景的免疫效应物。免疫缺陷病毒特异性 NAb 在感染猴免疫缺陷病毒 (SIV)、嵌合猴/人类免疫缺陷病毒 (SHIV) 和相关病毒的动物中的保护活性和机制已得到越来越多的研究。对此类模型的研究揭示了先前强调的针对体内免疫缺陷病毒复制的保护潜力。攻击前 NAb 滴度可以通过清除最早开始的病毒复制来提供针对 SIV/SHIV 感染的无菌保护，并可能调节先天免疫细胞反应。感染后足够的亚无菌 NAb 滴度还可以实现剂量依赖性的病毒血症减少，并且在某些较早的时间范围内增强适应性免疫细胞反应，甚至提供无反弹的病毒控制。在这里，我们概述了通过各种类型的 NAb 被动免疫获得的 SIV/SHIV 保护和病毒控制模式，并讨论如何将这些概念外推到基于 NAb 的 HIV 感染临床控制。
Neutralizing antibody (NAb) responses are promising immune effectors for control of human immunodeficiency virus (HIV) infection. Protective activity and mechanisms of immunodeficiency virus-specific NAbs have been increasingly scrutinized in animals infected with simian immunodeficiency virus (SIV), chimeric simian/human immunodeficiency virus (SHIV) and related viruses. Studies on such models have unraveled a previously underscored protective potential against in vivo immunodeficiency virus replication. Pre-challenge NAb titers feasibly provide sterile protection from SIV/SHIV infection by purging the earliest onset of viral replication and likely modulate innate immune cell responses. Sufficient sub-sterile NAb titers after established infection also confer dose-dependent reduction of viremia, and in certain earlier time frames augment adaptive immune cell responses and even provide rebound-free viral control. Here, we provide an overview of the obtained patterns of SIV/SHIV protection and viral control by various types of NAb passive immunizations and discuss how these notions may be extrapolated to NAb-based clinical control of HIV infection.