INFLUENCE OF DIETARY SUPPLEMENTATION WITH FISH ON PLASMA FATTY-ACID COMPOSITION IN CORONARY HEART-DISEASE PATIENTS
INFLUENCE OF DIETARY SUPPLEMENTATION WITH FISH ON PLASMA FATTY-ACID COMPOSITION IN CORONARY HEART-DISEASE PATIENTS
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DOI：
10.1159/000177842
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发表时间：
1995-01-01
影响因子：
3.9
通讯作者：
MATAIX, FJ
中科院分区：
文献类型：
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作者：
SANTOS, MJ;LOPEZJURADO, M;MATAIX, FJ
本文研究了20例冠心病急性心肌梗死患者膳食中添加鱼类对血浆脂肪酸水平的影响。研究分为三个阶段：住院期，为缺血性心脏病患者设计的心脏健康饮食8周后，以及n-3脂肪酸补充饮食4周后，用瘦肉和脂肪鱼代替红肉。在每个时段结束时，受试者回答一份48小时回忆问卷，以便我们评估他们对饮食的依从性，并采集血液样本用于测定血浆脂肪酸。鱼类饲料后硬脂脂肪酸显著降低。N-7和n-9脂肪酸在整个研究过程中没有明显变化。饲喂4周后，亚油酸及其长链衍生物二十二碳五烯酸（22:5 n-6）显著升高。第三期末n-3系列脂肪酸变化最显著的是亚麻酸显著减少，其长链衍生物二十碳五烯酸（20:5 n-3）和二十二碳六烯酸（22:6 n-3）显著增加。血浆脂肪酸水平的这些变化可能对冠心病有有益的影响。
The effects of dietary supplementation with fish on plasma fatty acid levels were studied in 20 coronary heart disease patients who had suffered acute myocardial infarction. The study was divided into three periods: hospital admission, after 8 weeks on a heart-healthy diet designed for patients with ischemic heart disease, and after 4 weeks on an n-3 fatty acid-supplemented diet in which red meat was replaced with lean and fatty fish. At the end of each period, the subjects responded to a 48-hour recall questionnaire, so that we could assess their compliance with the diet, and blood samples were collected for the determination of plasma fatty acids. Stearic fatty acid was significantly decreased after the fish diet. n-7 and n-9 fatty acids showed no significant changes throughout the study. At the end of the 4-week period when the fish diet was consumed, linoleic acid and its long-chain derivative docosapentaenoic acid (22:5 n-6) were significantly increased. The most notable changes in n-3 series fatty acids at the end of the third period were the significant decrease in linolenic acid and the significant increase in its long-chain derivatives eicosapentaenoic (20:5 n-3) and docosahexaneoic acid (22:6 n-3). These changes in plasma fatty acid levels may have beneficial effects on coronary heart disease.