Transforming growth factor-beta and extracellular matrix deposition in the kidney.
Transforming growth factor-beta and extracellular matrix deposition in the kidney.
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转化生长因子-β 和细胞外基质在肾脏中的沉积。
DOI：
10.1159/000422972
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发表时间：
1994
影响因子：
--
通讯作者：
Noble,NA
中科院分区：
文献类型：
--
作者：
Border,WA;Brees,D;Noble,NA
最近由Sporn和Roberts综述的越来越多的证据表明，细胞因子调节基本的生物学事件，如胚胎发生、发育、炎症和组织修复以及致癌作用。对细胞因子功能的进一步了解有望导致疾病的统一分子发病机制，其中通常，细胞因子起维持组织稳态和健康的作用。但是细胞因子作用的失调导致自身免疫性疾病、退行性疾病和纤维化疾病。健康和疾病的共同基础的一个例子是深刻的建议，“伤口是一个能自愈的肿瘤”，以及“伤口是不能自愈的肿瘤”的推论[3，4]。细胞因子研究的进展可能会导致一种新的分子医学，其中通过生物技术产生的细胞因子及其拮抗剂将为预防和治疗进行性肾病等严重疾病提供创新疗法[5]。细胞外基质的病理性积聚是导致终末期肾病的肾小球硬化和间质纤维化的中心生物学特征[6]。无论损伤的初始刺激是免疫的、血液动力学的还是代谢的，这都是正确的。细胞外基质的产生和沉积是皮肤创伤等刺激后组织修复和重塑的关键部分。转化生长因子-β（TGF-β）已被证明在
A growing body of evidence, recently reviewed by Sporn and Roberts [1, 2], indicates that cytokines regulate essential biological events such as embryogenesis, development, inflammation and tissue repair, and carcinogenesis. Improved understanding of cytokine function promises to lead to a unified molecular pathogenesis of disease in which normally, cytokines act to maintain tissue homeostasis and health. But dysregulation of cytokine action results in autoimmune, degenerative and fibrotic diseases. An example of this common basis for health and disease is the profound proposal that,'A wound is a tumor that heals itself,'and the corollary that,'Wounds are tumors that do not heal'[3, 4]. Advances in cytokine research are likely to lead to a new molecular medicine in which cytokines and their antagonists, produced by biotechnology, will provide innovative therapies for the prevention and treatment of serious disorders like progressive kidney disease [5].Pathological accumulation of extracellular matrix is the central biological feature of glomerulosclerosis and interstitial fibrosis that leads to end-stage renal disease [6]. And this is true whether the initial stimulus to injury is immunological, hemodynamic or metabolic. Production and deposition of extracellular matrix is a key part of tissue repair and remodeling which occurs following a stimulus such as dermal wound. Transforming growth factor-ẞ (TGF-β) has been shown to play a