Retinal nerve fiber layer thickness in patients with retinitis pigmentosa
Retinal nerve fiber layer thickness in patients with retinitis pigmentosa
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DOI：
10.1038/eye.2008.63
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发表时间：
2009-03-01
期刊：
影响因子：
3.9
通讯作者：
Yoshimura, N.
中科院分区：
文献类型：
--
作者：
Oishi, A.;Otani, A.;Yoshimura, N.
目的探讨视网膜色素变性（retinitis pigmentosa，RP）患者视网膜神经纤维层（retinal nerve fiber layer，RNFL）厚度的变化。采用多元线性回归模型分析了年龄、性别、偏侧性、遗传性、等效球镜屈光不正、视力和视野缺损程度对光学相干断层扫描测量的RNFL厚度的影响。模型的R-2倍数为0.349。在研究的变量中，年龄和男性是RNFL厚度变薄的重要风险因素。RNFL厚度与遗传、偏侧性、屈光不正、视力及视野缺损程度无关。结论RP患者RNFL厚度与视功能无关，与年龄无关。目前提出的疗法，包括光感受器拯救/移植和视觉假体，是基于这样的前提，即尽管光感受器严重丧失，但内部视网膜结构相对保留。目前的结果支持这一观点。
Purpose To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP).Design Cross-sectional observational study.Methods One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model.Results The average RNFL thickness was 104.1 +/- 21.7 mu m. The multiple R-2 for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect.Conclusion RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion.