Risk of Use of Antidepressants Among Children and Young Adults Exposed to the Death of a Parent
Risk of Use of Antidepressants Among Children and Young Adults Exposed to the Death of a Parent
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DOI：
10.1097/ede.0000000000000481
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发表时间：
2016-07-01
期刊：
影响因子：
5.4
通讯作者：
Bidstrup, Pernille Envold
中科院分区：
文献类型：
--
作者：
Appel, Charlotte Weiling;Johansen, Christoffer;Bidstrup, Pernille Envold
背景资料：深入了解父母早逝如何影响儿童和年轻人的心理健康，对于制定适当的支持性护理非常重要。本研究的目的是探讨早期父母死亡之间的关联之前，儿童达到30岁，随后使用抗抑郁药。方法：我们的全国范围内的人口为基础的队列出生在丹麦1970-1990年与后续的1997年至2009年期间，包括1,124,215人，其中71,380人丧失。我们使用泊松模型，以评估率比使用抗抑郁药根据早期父母death.Results：随访产生了13,074,146人年的风险，在此期间，93,347人使用抗抑郁药。经历父母早逝的人使用抗抑郁药的风险增加（男性：风险比，1.21; 95%置信区间，1.16，1.26;女性：1.23; 95%置信区间，1.19，1.27）。我们观察到，与其他原因相比，父母死于自杀的女性，失去母亲而不是父亲的女性，以及早期失去父母而不是后来失去父母的女性之间的联系更强。增加的风险仍然超过2年的loss.Conclusions：谁失去了父母的人使用抗抑郁药的风险增加。风险特别高的亚组包括因自杀而失去亲人的妇女、失去母亲的妇女和年轻时失去亲人的妇女。开始使用抗抑郁药的风险在损失后立即和之后都增加了。我们的研究结果支持父母早逝严重影响儿童的心理健康。
Background: Insight into how early parental death impact psychological well-being in children and young adults is important to developing suitable supportive care. The purpose of this study was to investigate the association between early parental death before the child reaches age 30 years and subsequent use of antidepressants.Methods: Our nationwide population-based cohort of persons born in Denmark in 1970-1990 with follow-up in the period 1997-2009 comprised 1,124,215 persons, of whom 71,380 were bereaved. We used Poisson models to assess rate ratios for use of antidepressants according to early parental death.Results: Follow-up yielded 13,074,146 person-years at risk during which 93,347 persons used antidepressants. Persons who experienced early parental death had an increased risk for use of antidepressants (men: risk ratio, 1.21; 95% confidence interval, 1.16, 1.26; women: 1.23; 95% confidence interval, 1.19, 1.27). We observed stronger associations for women whose parent died by suicide than from other causes, who lost their mother rather than their father, and who lost a parent early rather than later. The increased risk remained more than 2 years from the loss.Conclusions: Persons who lost a parent had an increased risk of use of antidepressants. Subgroups with particularly increased risk, included women, who were bereaved by suicides, who experienced loss of a mother, and who were bereaved when young. The risk of initiating antidepressant use was increased both immediately after the loss and later. Our results support that early parental death severely affects children's psychological well-being.