Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children
Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children
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DOI：
10.1093/humrep/dem257
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发表时间：
2008-01-01
影响因子：
6.1
通讯作者：
Ponjaert-Kristoffersen, I.
中科院分区：
文献类型：
--
作者：
Leunens, L.;Celestin-Westreich, S.;Ponjaert-Kristoffersen, I.
背景：这是第一次对8岁和10岁ICSI儿童的认知、心理社会、家庭关系和医学发展进行跟踪研究。讨论了关于10岁ICSI儿童认知和运动发育的第二波研究结果，并与8岁时的结果进行了比较。方法：对109例妊娠至少32周后经ICSI出生的10岁独生儿与90例自然受孕后出生的10岁独生儿的发育结局进行比较。结果：10岁ICSI儿童的总智商、言语智商和操作智商得分与SC儿童相当。ICSI和SC儿童在整体运动、手动和球类技能方面没有发现显著差异。ICSI儿童和女孩似乎分别比SC儿童和男孩拥有更好的平衡技能。关于长期随访，ICSI和SC儿童在10岁时的智商结果似乎是一致的(ICSI儿童在8岁时的得分略高)，可能表明随着时间的推移，ICSI组的母亲教育水平或刺激家庭环境的影响有所降低。结论：在这项跟踪研究中，ICSI和SC儿童在10岁之前表现出相似的认知和运动发育。这些发现与8岁时的研究结果一致。
BACKGROUND: This is the first follow-up study of the cognitive, psychosocial, family-relational and medical development of ICSI children at ages 8 and 10. Second-wave study results on the cognitive and motor development of 10-year-old ICSI children are discussed and compared with the outcome at 8 years. METHODS: Developmental outcomes of 109 10-year-old singletons born through ICSI after at least 32 weeks of gestation were compared with those of 90 singletons of the same age born after spontaneous conception (SC). The outcomes were also compared with the outcomes of the children at age 8. RESULTS: 10-year-old ICSI children obtained total, verbal and performance intelligence scores comparable to those of SC children. No significant differences were found between ICSI and SC children regarding overall motor, manual and ball skills. ICSI children and girls appear to have better balance skills than SC children and boys, respectively. With regard to long-term follow-up, the IQ results of ICSI and SC children at age 10 appear to have converged (from slightly higher scores in the ICSI children at age 8), probably indicating a decreased effect of maternal educational level or stimulating home environment in the ICSI group over time. CONCLUSIONS: In this follow-up study, ICSI and SC children show a comparable cognitive and motor development until the age of 10. These findings are in line with those obtained at age 8.