Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks
Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks
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DOI：
10.1073/pnas.1312902110
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发表时间：
2013-11-12
影响因子：
11.1
通讯作者：
Davis, Karen D.
中科院分区：
文献类型：
--
作者：
Kucyi, Aaron;Salomons, Tim V.;Davis, Karen D.
人类的思维常常会偏离他们直接的感官环境。目前尚不清楚这种走神是否是非系统性的，或者是否与个体关注显着刺激（例如疼痛及其相关的大脑结构/功能）的倾向有关。对疼痛与认知相互作用的研究通常考察注意力的明确操纵，而不是自发的思维漫游。在这里，我们试图更好地代表日常生活中疼痛的自然波动，因此我们评估了注意力自发脱离疼痛的行为和神经方面。我们发现，一个人关注疼痛的倾向与疼痛对其认知任务表现的破坏性影响有关。接下来，我们将行为发现与神经网络联系起来，并与疼痛期间功能性磁共振成像的惊人收敛证据以及思维游移、动态静息状态活动波动和扩散磁共振成像的思维探针相结合。我们发现（i）疼痛引起的默认模式网络（DMN）失活在思维远离疼痛时减弱； (ii) DMN 和导水管周围灰质 (PAG) 之间的功能连接波动动态跟踪远离疼痛的自发注意力； (iii) 在个体中，更强的 PAG-DMN 结构连接和更动态的静息状态 PAG-DMN 功能连接与思维远离疼痛的倾向相关。这些数据表明，在没有明确操纵的情况下，个体思维远离疼痛的倾向受到默认模式和镇痛下行调制网络内部和之间的功能和结构连接的促进。
Human minds often wander away from their immediate sensory environment. It remains unknown whether such mind wandering is unsystematic or whether it lawfully relates to an individual's tendency to attend to salient stimuli such as pain and their associated brain structure/function. Studies of pain-cognition interactions typically examine explicit manipulation of attention rather than spontaneous mind wandering. Here we sought to better represent natural fluctuations in pain in daily life, so we assessed behavioral and neural aspects of spontaneous disengagement of attention from pain. We found that an individual's tendency to attend to pain related to the disruptive effect of pain on his or her cognitive task performance. Next, we linked behavioral findings to neural networks with strikingly convergent evidence from functional magnetic resonance imaging during pain coupled with thought probes of mind wandering, dynamic resting state activity fluctuations, and diffusion MRI. We found that (i) pain-induced default mode network (DMN) deactivations were attenuated during mind wandering away from pain; (ii) functional connectivity fluctuations between the DMN and periaqueductal gray (PAG) dynamically tracked spontaneous attention away from pain; and (iii) across individuals, stronger PAG-DMN structural connectivity and more dynamic resting state PAG-DMN functional connectivity were associated with the tendency to mind wander away from pain. These data demonstrate that individual tendencies to mind wander away from pain, in the absence of explicit manipulation, are subserved by functional and structural connectivity within and between default mode and antinociceptive descending modulation networks.