Commentary: acetaldehyde and epithelial-to-mesenchymal transition in colon.
Commentary: acetaldehyde and epithelial-to-mesenchymal transition in colon.
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评论：乙醛和结肠中的上皮间质转化。
DOI：
10.1111/acer.12295
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Rao,RadhakrishnaK
中科院分区：
文献类型：
--
作者：
Rao,RadhakrishnaK
Elamin and colleagues in this issue report that acetaldehyde activates Snail, a transcription factor involved in epithelial‐to‐mesenchymal transition, in an intestinal epithelium. Snail mediates acetaldehyde‐induced tight junction disruption and increase in paracellular permeability. Results of this study and other previous studies raise several important questions. This commentary addresses these questions by discussing the acetaldehyde concentration in colon, disruption of epical junctional complexes in the intestinal epithelium by acetaldehyde, and the consequence of long‐term exposure to acetaldehyde on colonic epithelial regeneration, carcinogenesis, and metastases. The precise role of acetaldehyde in colonic epithelial modifications and promotion of colorectal cancers still remains to be understood.
