SncRNA (microRNA &snoRNA) opposite expression pattern found in multiple sclerosis relapse and remission is sex dependent.
SncRNA (microRNA &snoRNA) opposite expression pattern found in multiple sclerosis relapse and remission is sex dependent.
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DOI：
10.1038/srep20126
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发表时间：
2016-02-01
影响因子：
4.6
通讯作者：
Otaegui D
中科院分区：
文献类型：
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作者：
Muñoz-Culla M;Irizar H;Sáenz-Cuesta M;Castillo-Triviño T;Osorio-Querejeta I;Sepúlveda L;López de Munain A;Olascoaga J;Otaegui D
多发性硬化症（MS）是一种常见的炎症和退行性疾病，导致神经功能障碍。它影响年轻人，在妇女中的流行率较高。最常见的形式表现为一系列神经功能障碍的急性发作（复发），随后是恢复期（缓解）。最近，非编码RNA已成为转录组调控的新参与者，反过来，它们可能在MS发病机制中发挥重要作用。在这种情况下，我们的目的是调查参与的microRNA和snoRNA在外周血白细胞MS的复发-缓解动力学，揭示的分子和调控机制，这一复杂的过程。通过这种方法，我们发现一个小的非编码RNA（sncRNA）的子集在复发和缓解中发生了改变，揭示了性别依赖的意想不到的相反变化。此外，我们发现复发相关的miRNA签名调节白细胞中的一般代谢过程，并且缓解时改变的miRNA参与先天免疫的调节。我们观察到sncRNA失调在复发和缓解中是不同的，导致转录组调节的差异，并且该过程是性别依赖的。总之，复发和缓解在男性和女性中具有不同的分子背景。
Multiple sclerosis (MS) is a common inflammatory and degenerative disease that causes neurological disability. It affects young adults and its prevalence is higher in women. The most common form is manifested as a series of acute episodes of neurological disability (relapses) followed by a recovery phase (remission). Recently, non-coding RNAs have emerged as new players in transcriptome regulation, and in turn, they could have a significant role in MS pathogenesis. In this context, our aim was to investigate the involvement of microRNAs and snoRNAs in the relapse-remission dynamics of MS in peripheral blood leucocytes, to shed light on the molecular and regulatory mechanisms that underlie this complex process. With this approach, we found that a subset of small non-coding RNAs (sncRNA) is altered in relapse and remission, revealing unexpected opposite changes that are sex dependent. Furthermore, we found that a relapse-related miRNA signature regulated general metabolism processes in leucocytes, and miRNA altered in remission are involved in the regulation of innate immunity. We observed that sncRNA dysregulation is different in relapse and remission leading to differences in transcriptome regulation, and that this process is sex dependent. In conclusion, relapse and remission have a different molecular background in men and women.