HIGH TITERS OF AUTOANTIBODIES TO TOPOISOMERASE-I (SCL-70) IN SERA FROM SCLERODERMA PATIENTS
HIGH TITERS OF AUTOANTIBODIES TO TOPOISOMERASE-I (SCL-70) IN SERA FROM SCLERODERMA PATIENTS
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DOI：
10.1126/science.3003910
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发表时间：
1986-02-14
期刊：
影响因子：
56.9
通讯作者：
EARNSHAW, WC
中科院分区：
文献类型：
--
作者：
SHERO, JH;BORDWELL, B;EARNSHAW, WC
风湿性疾病患者通常存在针对核成分的循环自身抗体。这些抗体的临床意义存在争议，尽管在某些情况下它们对于疾病的诊断很有价值。本报告介绍了 Scl-70 的研究结果，Scl-70 是许多患有最严重的进行性系统性硬化症患者的血清所识别的自身抗原。通过三个独立的标准可以证明Scl-70是丰富的核酶DNA拓扑异构酶I。因此，现在可以使用高滴度和高亲和力的抗体探针来研究这种重要的核酶。
Patients with rheumatic diseases often have circulating autoantibodies to nuclear components. The clinical significance of the antibodies is controversial, although in some cases they are valuable in the diagnosis of the disease. This report presents results of a study of Scl-70, an autoantigen recognized by sera of many patients with the most severe form of progressive systemic sclerosis. It was possible to show, by three independent criteria, that Scl-70 is the abundant nuclear enzyme DNA topoisomerase I. Therefore, antibody probes of high titer and high affinity are now available for the study of this important nuclear enzyme.