Effect of light wavelength on suppression and phase delay of the melatonin rhythm
Effect of light wavelength on suppression and phase delay of the melatonin rhythm
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DOI：
10.1081/cbi-100107515
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发表时间：
2001-01-01
影响因子：
2.8
通讯作者：
Lack, LC
中科院分区：
文献类型：
--
作者：
Wright, HR;Lack, LC
比较了不同波长的光对褪黑素的抑制和唾液褪黑素节律的相移。比较的波长分别为660 nm(红色)、595 nm(琥珀色)、525 nm(绿色)、497 nm(蓝/绿)和470 nm(蓝色)。他们使用的发光二极管的照度相当于130MUW/cm(2)。15名志愿者参加了所有五种波长条件和一种无光控制条件，每种条件连续两个晚上进行。第一晚19：00-02：00每半小时采集一次唾液样本，第二天晚上01：00前每晚采集一次唾液样本。第一天晚上只在午夜至02：00进行光照。计算夜间褪黑素抑制百分率和每晚暗光褪黑素抑制百分率(DLMO)。波长较短的470、497和525 nm对褪黑素的抑制作用最大，为65%到81%。较短波长的DLMO延迟也在夜间最大，从27到36分钟不等。这一结果与暗视机制参与昼夜节律的调节是一致的。
Different wavelengths of light were compared for melatonin suppression and phase shifting of the salivary melatonin rhythm. The wavelengths compared were 660 nm (red), 595 nm (amber), 525 nm (green), 497 nm (blue/green), and 470 nm (blue). They were administered with light-emitting diodes equated for irradiance of 130 muW/cm(2). Fifteen volunteers participated in all five wavelength conditions and a no light control condition, with each condition conducted over two consecutive evenings. Half-hourly saliva samples were collected from 19:00 to 02:00 on night 1 and until 01:00 on night 2. Light was administered for the experimental conditions on the first night only from midnight to 02:00. Percentage melatonin suppression on night I and dim light melatonin onset (DLMO) for each night were calculated. The shorter wavelengths of 470, 497, and 525 nm showed the greatest melatonin suppression, 65% to 81%. The shorter wavelengths also showed the greatest DLMO delay on night 2, ranging from 27 to 36 min. The results were consistent with the involvement of a scotopic mechanism in the regulation of circadian phase.