Cardiovascular Morbidity Associated with Gonadotropin Releasing Hormone Agonists and an Antagonist
Cardiovascular Morbidity Associated with Gonadotropin Releasing Hormone Agonists and an Antagonist
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DOI：
10.1016/j.eururo.2013.10.032
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发表时间：
2014-03-01
期刊：
影响因子：
23.4
通讯作者：
Nilsson, Jan
中科院分区：
文献类型：
--
作者：
Albertsen, Peter C.;Klotz, Laurence;Nilsson, Jan
背景：雄激素剥夺疗法(ADT)与心血管发病率增加有关。目的：确定促性腺激素释放激素(GnRH)激动剂与拮抗剂应用后心血管发病率是否存在差异。设计、设置和参与者：收集2005至2012年间招募2328名男性的6个3期前瞻性随机试验的数据，以比较GnRH激动剂与拮抗剂的疗效。被招募的男性经病理证实患有前列腺癌，东方合作肿瘤学小组评分
Background: Androgen deprivation therapy (ADT) is associated with increased cardiovascular morbidity. Objective: To determine whether cardiovascular morbidity differs following initiation of gonadotropin-releasing hormone (GnRH) agonists compared with an antagonist.Design, setting, and participants: Pooled data from six phase 3 prospective randomized trials that recruited 2328 men between 2005 and 2012 to compare the efficacy of GnRH agonists against an antagonist. Men recruited had pathologically confirmed prostate cancer, an Eastern Cooperative Oncology Group score