The micro-environment of inflammation or Metchnikoff revisited.
The micro-environment of inflammation or Metchnikoff revisited.
复制标题
DOI：
10.1016/s0140-6736(55)93374-2
复制
发表时间：
1955-07
期刊：
影响因子：
168.9
通讯作者：
R. Dubos
中科院分区：
文献类型：
--
作者：
R. Dubos
1955年4月28日，在伦敦卫生和热带医学学院的伦敦大学演讲中，Dubos回顾了Metchnikoff的吞噬理论如何演变成一个复杂的宿主-寄生虫关系概念。这样的评论本身就是72年来文献中不断变化的观点的摘要，并不容易或有用地有助于进一步总结。Dubos提出了这样的观点，即自然和获得性抵抗力通常取决于炎症反应在病变内和周围创造对感染因子有害的微环境的能力;抵抗力通常取决于白细胞吞噬和破坏感染因子的能力。一般健康状况的紊乱可能会导致炎症区域的生化特征发生质和量的变化。因此，身体对感染的反应是在可能是代谢或精神起源的因素的控制下。这一概念部分地解释了这样一个事实，即对感染的易感性可以迅速而短暂地改变，而与感染个体的免疫状态无关。高迪
In this University of London lecture delivered at the London School of Hygiene and Tropical Medicine on April 28, 1955, Dubos reviews the way in which Metchnikoff's phagocytic theory has evolved into a sophisticated concept of host-parasite relationship. Such a review is itself an abstract of the changing views in the literature for 72 years and does not readily or usefully lend itself to further summarizing. Dubos presents the view that natural and acquired resistance very often depends upon the ability of the inflammatory response to create in and around the lesion a micro-environment inimical to the infectious agent; less often, resistance depends on the ability of leukocytes to engulf and destroy infectious agents. Disturbances in the general state of health may bring about qualitative and quantitative changes in the biochemical characteristics of the inflammatory area. Consequently the response of the body to infection is under the control of factors which may be metabolic or psychic in origin. This concept accounts in part for the fact that susceptibility to infection can change rapidly and transiently, independently of the immunological state of the infected individual.J. G. Goudie.