Activation of mitochondrial energy metabolism protects against cardiac failure.
Activation of mitochondrial energy metabolism protects against cardiac failure.
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DOI：
10.18632/aging.100234
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Ristow M
中科院分区：
文献类型：
--
作者：
Schulz TJ;Westermann D;Isken F;Voigt A;Laube B;Thierbach R;Kuhlow D;Zarse K;Schomburg L;Pfeiffer AF;Tschöpe C;Ristow M
Cardiac failure is the most prevalent cause of death at higher age, and is commonly associated with impaired energy homeostasis in the heart. Mitochondrial metabolism appears critical to sustain cardiac function to counteract aging. In this study, we generated mice transgenically over-expressing the mitochondrial protein frataxin, which promotes mitochondrial energy conversion by controlling iron-sulfur-cluster biogenesis and hereby mitochondrial electron flux. Hearts of transgenic mice displayed increased mitochondrial energy metabolism and induced stress defense mechanisms, while overall oxidative stress was decreased. Following standardized exposure to doxorubicin to induce experimental cardiomyopathy, cardiac function and survival was significantly improved in the transgenic mice. The insulin/IGF-1 signaling cascade is an important pathway that regulates survival following cytotoxic stress through the downstream targets protein kinase B, Akt, and glycogen synthase kinase 3. Activation of this cascade is markedly inhibited in the hearts of wild-type mice following induction of cardiomyopathy. By contrast, transgenic overexpression of frataxin rescues impaired insulin/IGF-1 signaling and provides a mechanism to explain enhanced cardiac stress resistance in transgenic mice. Taken together, these findings suggest that increased mitochondrial metabolism elicits an adaptive response due to mildly increased oxidative stress as a consequence of increased oxidative energy conversion, previously named mitohormesis. This in turn activates protective mechanisms which counteract cardiotoxic stress and promote survival in states of experimental cardiomyopathy. Thus, induction of mitochondrial metabolism may be considered part of a generally protective mechanism to prevent cardiomyopathy and cardiac failure.
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影响因子：
30.8
作者：
Puccio, H;Simon, D;Koenig, M
通讯作者：
Koenig, M
影响因子：
--
作者：
Kim, Jaetaek;Wende, Adam R.;Abel, E. Dale
通讯作者：
Abel, E. Dale
DOI：
10.1073/pnas.85.10.3585
发表时间：
1988-05-01
影响因子：
11.1
作者：
OLSON, RD;MUSHLIN, PS;BOUCEK, RJ
通讯作者：
BOUCEK, RJ
DOI：
10.1073/pnas.0611631104
发表时间：
2007-04-10
影响因子：
11.1
作者：
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通讯作者：
Ristow, Michael
DOI：
10.1152/ajpheart.01012.2001
发表时间：
2002-06-01
影响因子：
4.8
作者：
Hattori, R;Otani, H;Das, DK
通讯作者：
Das, DK