EFFECTS OF CAPSAICIN AND BRADYKININ ON AFFERENT-FIBERS WITH ENDINGS IN SKELETAL-MUSCLE
EFFECTS OF CAPSAICIN AND BRADYKININ ON AFFERENT-FIBERS WITH ENDINGS IN SKELETAL-MUSCLE
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DOI：
10.1161/01.res.50.1.133
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发表时间：
1982-01-01
影响因子：
20.1
通讯作者：
MITCHELL, JH
中科院分区：
文献类型：
--
作者：
KAUFMAN, MP;IWAMOTO, GA;MITCHELL, JH
将辣椒素注射到狗的去皮后肢的动脉供应中，引起心血管功能的反射性增加。辣椒素引起的心血管反射与静态运动引起的反射非常相似。传入纤维引发这些反射的增加，没有确定电生理，虽然他们的结束可能位于骨骼肌。测定辣椒素刺激的传入纤维。在麻醉的狗中，记录来自腓肠肌或股薄肌中具有末端的传入纤维的冲动，并将辣椒素（10-30 μ g/kg）注射到腹主动脉中。辣椒素刺激34组IV（C纤维）末梢中的24个，但仅刺激19组III（A δ）末梢中的5个。纤维）结束。缓激肽（0.5-1.5 μ g/kg）刺激33个IV组末梢中的17个和19个III组末梢中的9个。由辣椒素刺激的24个IV组传入神经的冲动活动从0.7 ± 0.5增加到0.7 ± 0.5。0.1达到9.3 ±的峰值。1.4冲击波，脉冲6 .+-开始击发。注射后1 s，并保持高于对照水平24 ± 1 s。5只辣椒素对30个I、II组肌传入的放电频率无明显影响。IV组肌肉传入主要负责引起反射增加心血管功能诱发注射辣椒素到狗的皮肤后肢的动脉供应。辣椒素可能是一种有用的药理学工具，用于确定刺激IV组肌肉传入引起的反射性自主神经效应。
Capsaicin, injected into the arterial supply of the skinned hindlimb of dogs, evokes reflex increases in cardiovascular function. The cardiovascular reflexes evoked by capsaicin are very similar to those evoked by static exercise. The afferent fibers initiating these reflex increases were not identified electrophysiologically, although their endings are probably located in skeletal muscle. The afferent fibers that are stimulated by capsaicin were determined. In anesthetized dogs, impulses from afferent fibers with endings in either the gastrocnemius or gracilis muscles were recorded and capsaicin (10-30 .mu.g/kg) was injected into the abdominal aorta. Capsaicin stimulated 24 of 34 group IV (C fiber) endings, but only 5 of 19 group III (A.delta. fiber) endings. Bradykinin (0.5-1.5 .mu.g/kg) stimulated 17 of 33 group IV endings and 9 of 19 group III endings. Impulse activity for the 24 group IV afferents stimulated by capsaicin increased from 0.7 .+-. 0.1 to a peak of 9.3 .+-. 1.4 imp[impulse]/s. Firing started 6 .+-. 1 s after injection and remained above control levels for 24 .+-. 5 s. Capsaicin had no significant effect on the firing rate of 30 group I and II muscle afferents. Group IV muscle afferents are primarily responsible for causing the reflex increases in cardiovascular function evoked by injecting capsaicin into the arterial supply of the skinned hindlimb of dogs. Capsaicin is likely to be a useful pharmacological tool with which to determine the reflex autonomic effects caused by stimulation of group IV muscle afferents.