Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics
Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics
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DOI：
10.1016/s0306-4522(97)00461-2
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发表时间：
1998-04-01
期刊：
影响因子：
3.3
通讯作者：
Bogerts, B
中科院分区：
文献类型：
--
作者：
Bernstein, HG;Stanarius, A;Bogerts, B
对10例精神分裂症、8例抑郁症和13例正常对照的下丘脑内侧核、视前内侧核、视内侧核、视交叉上核、视内侧核、视内侧核、漏斗上核、视交叉上核和下丘脑外侧核进行了一氧化氮合酶免疫反应神经元的神经解剖学研究。下丘脑一氧化氮合酶免疫反应阳性神经元绝大多数位于室旁核。大脑皮层神经元和小细胞侧室旁神经元都含有这种酶。一小部分免疫反应阳性的小细胞侧室旁神经元共同表达促肾上腺皮质激素释放激素。视上核不含一氧化氮合酶免疫反应神经元。正常对照组、精神分裂症患者和抑郁症患者右室旁核一氧化氮合酶阳性神经元的细胞计数显示抑郁症患者和精神分裂症患者右室旁核细胞密度明显低于对照组。抑郁症和精神分裂症患者脑室旁一氧化氮合酶免疫反应阳性神经元的总数明显少于正常人。抑郁症患者室旁一氧化氮合酶表达降低的病理生理意义可能与一氧化氮在促肾上腺皮质激素释放激素和精氨酸加压素和/或催产素的释放中的调节功能有关，已有报道在所谓的内源性精神病中过度表达，尤其是在抑郁症中。(C)1998年IBRO。爱思唯尔科学有限公司出版。
The neuroanatomical distribution of nitric oxide synthase-immunoreactive neurons was investigated in post moi rem hypothalami of 10 patients suffering from schizophrenia, eight patients with depression and 13 matched control cases.Neuronal nitric oxide synthase containing nerve cells were detected in several hypothalamic nuclei including the medial preoptic region, the ventromedial, infundibular and suprachiasmatic nuclei and the lateral hypothalamus. The vast majority of hypothalamic nitric oxide synthase-immunoreactive neurons was found to be located in the paraventricular nucleus. Both magno and parvocellular paraventricular neurons contained the enzyme. A small subset of immunoreactive parvocellular paraventricular neurons co-expresses corticotropin-releasing hormone. The supraoptic nucleus did not contain nitric oxide synthase-immunoreactive neurons. Cell counts of paraventricular nitric oxide synthase-positive neurons in controls, schizophrenics and depressed patients revealed a statistically significant reduction of cell density in the right paraventricular nucleus of depressed patients and schizophrenics as compared to controls. The total amount of nitric oxide synthase-immunoreactive paraventricular neurons was smaller in depressive and schizophrenic patients than in normal cases.The putative pathophysiologic significance of the reduced expression of paraventricular nitric oxide synthase in depressive patients might be related to the supposed regulatory function of nitric oxide in the release of corticotropin-releasing hormone and arginine-vasopressin and/or oxytocin, which have been reported to be over-expressed in the so-called endogenous psychoses, especially in depression. (C) 1998 IBRO. Published by Elsevier Science Ltd.