Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice
Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice
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类黄酮衍生物 (Fla-CN) 通过 microRNA 对高脂饮食诱导的肥胖小鼠的抗肥胖和抗糖尿病作用
DOI：
10.1016/j.ejps.2015.11.013
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发表时间：
2016-01-20
影响因子：
4.6
通讯作者：
Niu, Wen-Yan
中科院分区：
文献类型：
--
作者：
Qin, Nan;Chen, Ying;Niu, Wen-Yan
叶黄素(3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl]kaempferol，FLA-CN)是一种半合成的类黄酮类化合物，可降低高脂饮食诱导的肥胖小鼠的全身肥胖，改善代谢脂代谢紊乱，改善胰岛素敏感性，并有益于其他以胰岛素抵抗为特征的疾病。胰岛素敏感性的改善和体重增加的减少与瘦素和脂联素水平的变化有关。结果表明，FLA-CN治疗可增加肝脏和脂肪组织中pAMPK和miR-27的表达。同时，我们发现多种成脂基因的表达下调，这些基因是miR-27的靶基因。这是首次报道类黄酮衍生物对miR-27在啮齿动物体内的作用。FLA-CN可能通过激活AMPK、增强miR-27表达等多种途径发挥作用。(C)2015爱思唯尔B.V.保留所有权利。
3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl]kaempferol (Fla-CN), a semi-synthesized flavonoid derivative of tiliroside, reduces whole-body adiposity, ameliorates metabolic lipid disorder, improves insulin sensitivity and benefits other disorders characterized by insulin resistance in high fat diet induced obesity mice. The improvement of insulin sensitivity and the reduction of weight gain are correlated with the changes of leptin and adiponectin levels. As a result, Fla-CN treatment could increase the expressions of pAMPK and miR-27 in the liver and adipose tissues. Meanwhile, we discovered that the expressions of various adipogenesis genes were downregulated, which were target genes of miR-27. This is the first report for the action of miR-27 by flavonoid derivative in rodents. The action of Fla-CN might be through multiple approaches including AMPK activation and enhancement in miR-27 expression. (C) 2015 Elsevier B.V. All rights reserved.