Postprandial Effect of a High-Fat Meal on Endotoxemia in Arab Women with and without Insulin-Resistance-Related Diseases.
Postprandial Effect of a High-Fat Meal on Endotoxemia in Arab Women with and without Insulin-Resistance-Related Diseases.
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DOI：
10.3390/nu7085290
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发表时间：
2015-08-04
期刊：
影响因子：
5.9
通讯作者：
McTernan PG
中科院分区：
文献类型：
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作者：
Al-Disi DA;Al-Daghri NM;Khan N;Alfadda AA;Sallam RM;Alsaif M;Sabico S;Tripathi G;McTernan PG
这项研究确定了高脂肪膳食对阿拉伯成年女性循环内毒素和心脏代谢指数的影响。该队列由 92 名同意的沙特女性（18 名非糖尿病 (ND)）对照受试者组成；年龄24.4±7.9岁；体重指数（BMI）22.2±2.2Kg/m2），24名超重/肥胖（称为超重+（overweight+））受试者（年龄32.0±7.8岁；BMI 28.5±1.5Kg/m2）和50名2型糖尿病（T2DM）患者（年龄41.5±6.2岁；BMI 35.2±7.7公斤/平方米）。所有受试者在禁食 12-14 小时过夜后均接受高脂肪膳食（标准化膳食：75 克脂肪、5 克碳水化合物、6 克蛋白质）。进行人体测量，并连续测量餐后四个小时的空腹血糖、血脂和内毒素。超重+和 T2DM 患者在食用高脂肪餐前，内毒素水平显着高于对照组（p < 0.05）。此外，餐后心脏代谢变化导致 T2DM 受试者比其他群体更有害的风险状况，其中葡萄糖、甘油三酯、高密度脂蛋白胆固醇（HDL-胆固醇）和胰岛素水平的一系列变化最显着（p 值 < 0.05）。给不同代谢状态的受试者提供相同的单餐对心脏代谢健康有不同的影响。在患有 T2DM 的阿拉伯受试者中，高脂肪膳食会加剧内毒素血症，并伴随心脏代谢风险状况的平行增加，这表明患有或不患有 T2DM 的患者的疾病发病机制存在差异，这是由于心脏代谢风险状况的改变，而不是高脂膳食引起的代谢性内毒素血症的差异。
This study determined the effects of a high-fat meal on circulating endotoxin and cardiometabolic indices in adult Arab women. The cohort consisted of 92 consenting Saudi women (18 non-diabetic (ND)) control subjects; Age 24.4 ± 7.9 year; body mass index (BMI) 22.2 ± 2.2 Kg/m2), 24 overweight/obese (referred to as overweight-plus (overweight+)) subjects (Age 32.0 ± 7.8 year; BMI 28.5 ± 1.5 Kg/m2) and 50 type 2 diabetes mellitus (T2DM) patients (Age 41.5 ± 6.2 year; BMI 35.2 ± 7.7 Kg/m2). All were given a high-fat meal (standardized meal: 75 g fat, 5 g carbohydrate, 6 g protein) after an overnight fast of 12–14 h. Anthropometrics were obtained and fasting blood glucose, lipids, and endotoxin were serially measured for four consecutive postprandial hours. Endotoxin levels were significantly elevated prior to a high-fat meal in the overweight+ and T2DM than the controls (p < 0.05). Furthermore, the postprandial cardiometabolic changes led to a more detrimental risk profile in T2DM subjects than other groups, with serial changes most notable in glucose, triglycerides, high density lipoprotein-cholesterol (HDL-cholesterol), and insulin levels (p-values < 0.05). The same single meal given to subjects with different metabolic states had varying impacts on cardiometabolic health. Endotoxemia is exacerbated by a high-fat meal in Arab subjects with T2DM, accompanied by a parallel increase in cardiometabolic risk profile, suggesting disparity in disease pathogenesis of those with or without T2DM through the altered cardiometabolic risk profile rather than variance in metabolic endotoxinaemia with a high-fat meal.