Neural substrates of early executive function development
Neural substrates of early executive function development
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DOI：
10.1016/j.dr.2019.100866
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发表时间：
2019-06-01
影响因子：
6.6
通讯作者：
Holmboe, Karla
中科院分区：
文献类型：
--
作者：
Fiske, Abigail;Holmboe, Karla
在过去的十年中，神经影像技术的进步催生了大量研究执行功能（EF）的神经基础的研究。 EF 长期以来一直与前额皮质 (PFC) 联系在一起，它既涉及统一的、通用的元素，也涉及工作记忆、抑制控制和设定转换等独特的、可分离的元素。我们将强调利用神经影像技术的进步来解答早期 EF 发展领域中一些最紧迫问题的价值。首先，本综述将探讨 EF 各元素的发育和神经底物。其次，将检查婴儿期和整个儿童期 PFC 中发生的结构、解剖学和生化变化，以探讨这些变化对 EF 发展的重要性。第三，回顾了 PFC 区域和其他大脑区域之间的连接在 EF 发展中的重要性。最后，在这篇综述中，我们将讨论神经影像技术的最新发展，以及未来进一步阐明早期 EF 发展的神经基础的影响。
In the last decade, advances in neuroimaging technologies have given rise to a large number of research studies that investigate the neural underpinnings of executive function (EF). EF has long been associated with the prefrontal cortex (PFC) and involves both a unified, general element, as well as the distinct, separable elements of working memory, inhibitory control and set shifting. We will highlight the value of utilising advances in neuroimaging techniques to uncover answers to some of the most pressing questions in the field of early EF development. First, this review will explore the development and neural substrates of each element of EF. Second, the structural, anatomical and biochemical changes that occur in the PFC during infancy and throughout childhood will be examined, in order to address the importance of these changes for the development of EF. Third, the importance of connectivity between regions of the PFC and other brain areas in EF development is reviewed. Finally, throughout this review more recent developments in neuroimaging techniques will be addressed, alongside the implications for further elucidating the neural substrates of early EF development in the future.