The Many Faces of Endothelial Microparticles
The Many Faces of Endothelial Microparticles
复制标题
DOI：
10.1161/atvbaha.110.218123
复制
发表时间：
2011-01-01
影响因子：
8.7
通讯作者：
Boulanger, Chantal M.
中科院分区：
文献类型：
--
作者：
Dignat-George, Francoise;Boulanger, Chantal M.
内皮微粒(EMP)是由活化或凋亡的内皮细胞脱落的复杂的泡状结构。它们在凝血、炎症、内皮功能和血管生成等方面发挥重要作用，从而扰乱血管内稳态，促进血管疾病的进展。作为原因或结果，血管疾病患者血浆中的EMP水平升高，可作为血管内皮细胞功能的替代标志。最近的数据挑战了EMP的假定有害作用，因为它们可以促进细胞存活，发挥抗炎作用，抵消凝血过程，或诱导内皮细胞再生。本文就EMP在血管内稳态中的矛盾作用作一综述。(动脉血栓血管生物)2011；31：27-33。)
Endothelial microparticles (EMP) are complex vesicular structures shed from activated or apoptotic endothelial cells. They play a remarkable role in coagulation, inflammation, endothelial function, and angiogenesis and thus disturb the vascular homeostasis, contributing to the progression of vascular diseases. As a cause or a consequence, elevated levels of EMP were found in plasma from patients with vascular diseases, where they serve as a surrogate marker of endothelial function. More recent data challenged the presumed deleterious role of EMP because they could promote cell survival, exert antiinflammatory effects, counteract coagulation processes, or induce endothelial regeneration. This review focuses on the ambivalent role of EMP in vascular homeostasis. (Arterioscler Thromb Vasc Biol. 2011;31:27-33.)