Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer's disease
Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer's disease
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DOI：
10.1007/s00259-007-0454-x
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发表时间：
2007-10-01
影响因子：
9.1
通讯作者：
Yamada, Masahito
中科院分区：
文献类型：
--
作者：
Samuraki, Miharu;Matsunari, Ichiro;Yamada, Masahito
目的虽然F-18-氟脱氧葡萄糖（FDG）PET是一种成熟的评估脑葡萄糖利用的成像技术，但由于PET有限的空间分辨率，部分容积效应（PVE）的存在使示踪剂浓度的准确测量混淆，这在萎缩的脑中尤其如此，例如阿尔茨海默病（AD）患者所遇到的脑。我们的目的是探讨PVE校正对轻度AD患者FDG PET结合基于体素的形态测量（VBM）的影响。方法39例AD患者和73例对照者进行FDG PET和MRI检查。PVE校正的灰质PET图像使用基于MRI的三室法获得。结果PVE矫治前，AD患者扣带回后部（PCG）和顶颞叶（PTL）FDG摄取明显减少，PVE矫治后仍持续存在。值得注意的是，PVE校正显示相对保存的FDG摄取在海马区，尽管在内侧颞叶（MTL）的灰质损失所揭示的VBM。结论FDG摄取在PCG和PTL减少AD无论是否PVE校正，支持的概念，减少FDG摄取在这些领域是不是萎缩的结果。此外，MTL（包括海马区）灰质组织的FDG摄取相对保留，表明代偿机制可能在轻度AD患者中发挥作用。
Purpose Although F-18-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brains such as those encountered in patients with Alzheimer's disease (AD). Our aim was to investigate the effects of PVE correction on FDG PET in conjunction with voxel-based morphometry (VBM) in patients with mild AD.Methods Thirty-nine AD patients and 73 controls underwent FDG PET and MRI. The PVE-corrected grey matter PET images were obtained using an MRI-based three-compartment method. Additionally, the results of PET were compared with grey matter loss detected by VBM.Results Before PVE correction, reduced FDG uptake was observed in posterior cingulate gyri (PCG) and parieto-temporal lobes (PTL) in AD patients, which persisted after PVE correction. Notably, PVE correction revealed relatively preserved FDG uptake in hippocampal areas, despite the grey matter loss in medial temporal lobe (MTL) revealed by VBM.Conclusion FDG uptake in PCG and PTL is reduced in AD regardless of whether or not PVE correction is applied, supporting the notion that the reduced FDG uptake in these areas is not the result of atrophy. Furthermore, FDG uptake by grey matter tissue in the MTL, including hippocampal areas, is relatively preserved, suggesting that compensatory mechanisms may play a role in patients with mild AD.