Household presentation of acute gastroenteritis in a primary care sentinel network: retrospective database studies
Household presentation of acute gastroenteritis in a primary care sentinel network: retrospective database studies
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DOI：
10.1186/s12889-020-08525-8
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发表时间：
2020-04-05
影响因子：
4.5
通讯作者：
Joy, Mark
中科院分区：
文献类型：
--
作者：
de Lusignan, Simon;Sherlock, Julian;Joy, Mark
研究背景急性胃肠炎（AGE）是一种高度传染性疾病，在个体间和家庭内迅速传播。轮状病毒疫苗于2013年在英国推出。研究目的是调查25年来急性胃肠炎发病率的变化情况以及自2013年以来AGE的家庭发病率。方法重复横断面研究皇家全科医师学院研究和监测中心网络。我们使用负二项模型报告了最近5年的发病率比（IRR）。我们还使用共享伽马脆弱模型（2013-2017）进行了回顾性队列分析。结果在横断面分析中，有一个5岁以下儿童的家庭年龄的IRR为12.20（95%CI 11.08-13.45-，p < 0.01），
BackgroundAcute gastroenteritis (AGE) is a highly transmissible condition spreading rapidly between individuals and within households. Rotavirus vaccination was introduced in the UK in 2013. The study objectives were to investigate how acute gastroenteritis incidence changed over 25years and household incidence of AGE since 2013.MethodsRepeated cross-sectional study of Royal College of General Practitioners Research and Surveillance Centre network. We used a negative binomial model to report incidence rate ratio (IRR) using the last 5 years data. We also conducted a retrospective cohort analysis, using a shared gamma frailty model (2013-2017). We explored the impact of child under 5- years, household size, socioeconomic status quintile, and rurality.ResultsIn the cross-sectional analysis, the IRR of AGE in households with a child of under 5years was 12.20 (95%CI 11.08-13.45-, p