Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.
Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.
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伴有髓样抗原表达的颗粒状急性 B 细胞淋巴细胞白血病中嗜酸性粒细胞增多。
DOI：
10.1111/j.1442-200x.2011.03471.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Nonoyama S.
中科院分区：
文献类型：
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作者：
Kobayashi D;Kogawa K;Imai K;Tanaka T;Sada A;Nonoyama S.
急性淋巴细胞白血病伴嗜酸性粒细胞增多症是一种罕见但独特的临床实体。在ALLEo患者中可观察到特发性高嗜酸性粒细胞综合征（HES）的临床特征。我们报告1例10岁女孩，最初怀疑为HES，但进一步检查证实诊断为急性B细胞淋巴细胞白血病伴髓系抗原表达。化疗的临床反应非常好，达到完全缓解4年。血清白细胞介素-3和-5在就诊时升高，诱导治疗后随着嗜酸性粒细胞增多消失而恢复正常，支持ALLEo中嗜酸性粒细胞增多的反应性。在将其归因于HES之前，应考虑高嗜酸性粒细胞增多症患者的血液恶性肿瘤。
Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper‐eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10‐year‐old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B‐cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin‐3 and ‐5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper‐eosinophilia, before attributing it to HES.