Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors
Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors
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DOI：
10.1073/pnas.1119449109
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发表时间：
2012-06-05
影响因子：
11.1
通讯作者：
Benowitz, Larry
中科院分区：
文献类型：
--
作者：
de Lima, Silmara;Koriyama, Yoshiki;Benowitz, Larry
成熟的视神经在受伤时不能再生，使创伤性神经损伤或青光眼等疾病的受害者具有不可逆的视力丧失。最近的研究已经确定了刺激视网膜神经节细胞通过视神经再生轴突的方法，但成熟的轴突是否可以重新进入大脑，导航到适当的目标区域或恢复视力仍然是未知的。我们在这里表明，有足够的刺激，视网膜神经节细胞能够再生轴突的整个长度的视觉通路，并进入外侧膝状体核，上级丘，和其他视觉中心。再生部分恢复视动反应，深度知觉和昼夜光诱导，证明了在成熟哺乳动物视神经损伤后重建视觉中枢回路的可行性。
The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic nerve, but it remains unknown whether mature axons can reenter the brain, navigate to appropriate target areas, or restore vision. We show here that with adequate stimulation, retinal ganglion cells are able to regenerate axons the full length of the visual pathway and on into the lateral geniculate nucleus, superior colliculus, and other visual centers. Regeneration partially restores the optomotor response, depth perception, and circadian photoentrainment, demonstrating the feasibility of reconstructing central circuitry for vision after optic nerve damage in mature mammals.