Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO(2)-Supported Palladium Catalyst under Continuous-Flow Conditions.
Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO(2)-Supported Palladium Catalyst under Continuous-Flow Conditions.
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DOI：
10.1002/open.201600166
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发表时间：
2017-04
期刊：
影响因子：
2.3
通讯作者：
Kobayashi S
中科院分区：
文献类型：
--
作者：
Saito Y;Ishitani H;Ueno M;Kobayashi S
介绍了在液相连续流动条件下，非均相催化剂催化氰化物加氢制伯胺的反应过程。新开发的聚硅烷/二氧化硅负载钯是一种有效的催化剂，在温和的反应条件下，各种腈几乎可以定量地转化为伯胺盐。有趣的是，在间歇条件下得到了复杂的混合物。寿命试验表明，该催化剂的活性保持在30 0 h以上(吨≥10 000)，没有发生选择性损失，也没有发生金属浸出现象。利用这种连续流加氢法，成功地合成了抗抑郁药文拉法辛。
Hydrogenation of nitriles to primary amines with heterogeneous catalysts under liquid‐phase continuous‐flow conditions is described. Newly developed polysilane/SiO2‐supported Pd was found to be an effective catalyst and various nitriles were converted into primary amine salts in almost quantitative yields under mild reaction conditions. Interestingly, a complex mixture was obtained under batch conditions. Lifetime experiments showed that this catalyst remained active for more than 300 h (TON≥10 000) without loss of selectivity and no metal leaching from the catalyst occurred. By using this continuous‐flow hydrogenation, synthesis of venlafaxine, an antidepressant drug, has been accomplished.