RNA EDITING IN NEWCASTLE-DISEASE VIRUS
RNA EDITING IN NEWCASTLE-DISEASE VIRUS
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DOI：
10.1099/0022-1317-74-12-2539
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发表时间：
1993-12-01
影响因子：
3.8
通讯作者：
EMMERSON, PT
中科院分区：
文献类型：
--
作者：
STEWARD, M;VIPOND, IB;EMMERSON, PT
通过对克隆的纽卡斯尔疫病毒（NDV）基因组RNA和mRNA的序列分析，研究了NDV P基因的共转录编辑。已经获得了非模板G核苷酸的特异性插入的证据，其结果是产生三个群体的P基因衍生的mRNA。这三个群体编码的蛋白质（P、V和W）具有共同的N末端区域，但在其C末端利用三个不同的阅读框。巧合的是，NDV通过以类似于仙台病毒和麻疹病毒的方式插入非模板化的G残基来编辑其P基因mRNA（P -> V编辑），尽管其与猿病毒5型、腮腺炎和相关病毒组的明显更接近的进化关系，所述病毒组编辑V基因组序列以产生编码功能性P蛋白的mRNA（V -> P编辑）。
The co-transcriptional editing of the Newcastle disease virus (NDV) P gene has been studied by sequence analysis of cloned viral genomic RNA and mRNA. Evidence has been obtained for the specific insertion of non-templated G nucleotides, the consequence of which is the generation of three populations of P gene-derived mRNAs. The three populations encode proteins (P, V and W) which have a common N-terminal region, but which utilize three different reading frames at their C termini. Paradoxically, NDV edits its P gene mRNA by the insertion of non-templated G residues in a manner similar to Sendai and measles viruses (P --> V editing) despite its apparent closer evolutionary relationship to the simian virus type 5, mumps and related group of viruses which edit a V genomic sequence to generate an mRNA to encode a functional P protein (V --> P editing).