Microwave-assisted solid-phase synthesis of pH-responsive polyaspartamide derivatives.
Microwave-assisted solid-phase synthesis of pH-responsive polyaspartamide derivatives.
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DOI：
10.1016/j.carbpol.2012.04.012
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发表时间：
2012-07
影响因子：
11.2
通讯作者：
Xiangang Huang;Xulin Jiang;R. Zhuo
中科院分区：
文献类型：
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作者：
Xiangang Huang;Xulin Jiang;R. Zhuo
可生物降解的刺激响应性聚合物在生物医学领域引起了越来越多的关注。本文以聚N-取代α/β-天冬酰胺为原料，采用微波辅助法，在无溶剂、无催化剂的条件下合成了一系列pH响应性的聚N-取代α/β-天冬酰胺衍生物。聚合物结构经1H NMR、IR和UV-Vis光谱确证。在较短的反应时间（13- 18 min）下，微波加热得到的酸酐改性聚酰胺衍生物的取代度（DS）比常规加热（24 h）得到的高2 ~ 3倍。此外，利用动态光散射（DLS）研究了聚酰胺衍生物在pH诱导下的相变行为。所得聚合物的临界pH转变（pHtr）随着聚合物的DS的增加而增加。通过测定聚合物的亲水亲油平衡（HLB），研究了聚合物结构与pH值的关系。
Biodegradable stimulus-responsive polymers have attracted more attention in biomedical fields. Here, a series of pH-responsive polyaspartamide derivatives are successfully synthesized from poly(N-substituted α/β-asparagines) by a facile, solvent-free and catalyst-free microwave-assisted method. The polymer structure is confirmed by1H NMR, IR and UV–Vis spectra. With much shorter reaction time (13–18min), the degree of substitution (DS) of the anhydride-modified polyaspartamide derivatives obtained by microwave heating is two to three times higher as that obtained by conventional heating in DMF (24h). In addition, pH-induced phase transition behavior of polyaspartamide derivatives is investigated by dynamic light scattering (DLS). The critical pH transition (pHtr) of the resulted polymers increases with increasing DS of the polymers. The hydrophile–lipophile balance (HLB) of the obtained polymers is evaluated to study the relationship between pHtr and polymer structure.