Biological roles and therapeutic potential of G protein-coupled receptors for free fatty acids and metabolic intermediates
Biological roles and therapeutic potential of G protein-coupled receptors for free fatty acids and metabolic intermediates
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DOI：
10.7600/jpfsm.5.213
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Kenji Suzuki;Takako Kaneko-Kawano
中科院分区：
文献类型：
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作者：
Kenji Suzuki;Takako Kaneko-Kawano
一些G蛋白偶联受体已被发现，它们传递信号以响应饮食中的游离脂肪酸(FFAs)以及内源性代谢产物，如乳酸和3-羟基丁酸盐。这些受体被证明可以感知身体能量底物或代谢状态的水平，并调节各种器官的新陈代谢和内分泌功能，以维持能量平衡。脂肪酸和羟基羧酸(HCAs)的受体似乎与几种代谢紊乱有关，包括肥胖、糖尿病和动脉粥样硬化。本文综述了FFA和HCA受体在生理学和病理生理学中的作用，并讨论了它们在代谢性疾病治疗中的意义。
Several G protein-coupled receptors that transmit signals in response to dietary free fatty acids (FFAs) as well as endogenous metabolites, such as lactate and 3-hydroxybutyrate, have been discovered. These receptors are shown to sense levels of energy substrates or metabolic states of the body, and regulate metabolism and endocrine functions of various organs to maintain energy homeostasis. The receptors for FFAs and hydroxy carboxylic acids (HCAs) appear to be involved in several metabolic disorders including obesity, diabetes and atherosclerosis. In this review, we summarize the functions of FFA and HCA receptors in physiology and pathophysiology, and discuss their implications for the treatment of metabolic diseases.