The association between immune activation and manic symptoms in patients with a depressive disorder
The association between immune activation and manic symptoms in patients with a depressive disorder
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DOI：
10.1038/tp.2013.87
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发表时间：
2013-10-01
影响因子：
6.8
通讯作者：
Schoevers, R. A.
中科院分区：
文献类型：
--
作者：
Becking, K.;Boschloo, L.;Schoevers, R. A.
虽然最近的研究表明，免疫过程中起着重要的作用，情绪障碍的病理生理，免疫激活可能只存在于特定的亚组的患者。我们的研究旨在研究在2年的随访中，抑郁症患者的免疫激活是否与（a）躁狂症状的存在和（B）躁狂症状的发作相关。基线时患有抑郁症的患者（N = 957）和健康对照组（N = 430）选自荷兰抑郁和焦虑研究。评估包括基线和两年随访时的终生躁狂症状，以及基线时的C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）。在抑郁症患者中，免疫激活与基线时是否存在终生躁狂症状无关。然而，与那些在2年内没有出现躁狂症状的人相比，出现躁狂症状的抑郁症男性的CRP水平显著升高（P
Although recent studies have shown that immunological processes play an important role in the pathophysiology of mood disorders, immune activation may only be present in specific subgroups of patients. Our study aimed to examine whether immune activation was associated with (a) the presence of manic symptoms and (b) the onset of manic symptoms during 2 years of follow-up in depressed patients. Patients with a depressive disorder at baseline (N = 957) and healthy controls (N = 430) were selected from the Netherlands Study of Depression and Anxiety. Assessments included lifetime manic symptoms at baseline and two-year follow up, as well as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) at baseline. Within depressed patients, immune activation was not related to the presence or absence of lifetime manic symptoms at baseline. However, CRP levels were strongly elevated in depressed men who developed manic symptoms compared with those who did not develop manic symptoms over 2 years (P