BRAIN IS THE MAJOR SITE OF ESTROGEN SYNTHESIS IN A MALE SONGBIRD
BRAIN IS THE MAJOR SITE OF ESTROGEN SYNTHESIS IN A MALE SONGBIRD
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DOI：
10.1073/pnas.88.10.4191
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
ARNOLD, AP
中科院分区：
文献类型：
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作者：
SCHLINGER, BA;ARNOLD, AP
雀形目鸟类控制鸣叫的神经系统在发育和成年期都会经历显著的形态和功能变化，其中许多变化受到雌激素的调节。雄性鸣禽血液中雌激素水平较高，并在去势后持续存在。我们测量了成年雄性和雌性斑马雀不同组织中芳香酶的活性，芳香酶是一种将雄激素转化为雌激素的酶。不出所料，芳香酶活性存在于男性下丘脑/视前区、垂体和女性卵巢中，但在男性和女性的整个端脑中都异常活跃。相比之下，在男性的睾丸、肾上腺或其他组织中没有检测到活动。这些结果表明，大脑是雄性斑雀体内循环雌激素的来源，雌激素对SING系统的作用是局部芳构化而不是外周芳构化的结果。
The neural system controlling song in passerine birds can undergo striking morphological and functional changes during both development and adulthood, and many of these changes are regulated by estrogenic hormones. Estrogens circulate at high levels in blood of male songbirds and persist after castration. We measured the activity of aromatase, the enzyme that converts androgens to estrogens, in various tissues from adult male and female zebra finches. As expected, aromatase activity was present in male hypothalamus/preoptic area and pituitary and female ovary, but aromatase was unusually active in whole telencephalon of males and females. By contrast, activity was undetected in testes, adrenals, or other tissues of males. These results suggest that brain is the source of circulating estrogens in the male zebra finch and that estrogen actions on the song system result from local rather than peripheral aromatization.