Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease - The Framingham heart study
Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease - The Framingham heart study
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DOI：
10.1001/archneur.63.11.1545
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
Wolf, Philip A.
中科院分区：
文献类型：
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作者：
Schaefer, Ernst J.;Bongard, Vanina;Wolf, Philip A.
背景：二十二碳六烯酸（DHA）是大脑中丰富的脂肪酸。在饮食中，DHA主要存在于多脂鱼类中。痴呆症患者大脑和血浆中的 DHA 含量已被证明降低。目的：确定血浆磷脂酰胆碱 (PC) DHA 含量是否与患痴呆症的风险相关。设计、背景和参与者：一项前瞻性随访研究，对象为 899 名基线时没有痴呆症的男性和女性，平均年龄为 76.0 岁，随访平均年龄为 9.1 岁 全因痴呆和阿尔茨海默病的发展年数。 主要结果指标：在基线时测量血浆 PC 脂肪酸水平。采用Cox比例回归分析根据基线血浆水平评估全因痴呆和阿尔茨海默病的相对风险。结果：随访期间出现99例新发痴呆病例（其中71例为阿尔茨海默病）。调整年龄、性别、载脂蛋白 E ε 4 等位基因、血浆同型半胱氨酸浓度和教育水平后，基线血浆 PC DHA 水平上四分位的受试者与下 3 个四分位的受试者相比，发生全因痴呆的相对风险为 0.53（95% 置信区间，0.29-0.97；P = .04），发生全因痴呆的相对风险为 0.61。 阿尔茨海默病（95% 置信区间，0.31-1.18；P = .14）。在 488 名参与者中，血浆 PC、DHA 水平处于上四分之一的受试者的平均 DHA 摄入量为 0.18 克/天，平均每周摄入 3.0 份鱼 (P < .001)。我们没有发现其他显着关联。结论：在 Framingham 心脏研究中，血浆 PC DHA 水平的前四分之一与患全因痴呆症的风险显着降低 47% 相关。
Background: Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia.Objective: To determine whether plasma phosphatidylcholine (PC) DHA content is associated with the risk of developing dementia.Design, Setting, and Participants: A prospective follow-up study in 899 men and women who were free of dementia at baseline, had a median age of 76.0 years, and were followed up for a mean of 9.1 years for the development of all-cause dementia and Alzheimer disease.Main Outcome Measures: Plasma PC fatty acid levels were measured at baseline. Cox proportional regression analysis was used to assess relative risks of all-cause dementia and Alzheimer disease according to baseline plasma levels.Results: Ninety-nine new cases of dementia (including 71 of Alzheimer disease) occurred during the follow-up. After adjustment for age, sex, apolipoprotein E epsilon 4 allele, plasma homocysteine concentration, and education level, subjects in the upper quartile of baseline plasma PC DHA levels, compared with subjects in the lower 3 quartiles, had a relative risk of 0.53 of developing all-cause dementia (95% confidence interval, 0.29-0.97; P = .04) and 0.61 of developing Alzheimer disease (95% confidence interval, 0.31-1.18; P = .14). Subjects in the upper quartile of plasma PC, DHA levels had a mean DHA intake of 0.18 g/d and a mean fish intake of 3.0 servings per week (P < .001) in a subset of 488 participants. We found no other significant associations.Conclusion: The top quartile of plasma PC DHA level was associated with a significant 47% reduction in the risk of developing all-cause dementia in the Framingham Heart Study.