Sterilization techniques for biodegradable scaffolds in tissue engineering applications.
Sterilization techniques for biodegradable scaffolds in tissue engineering applications.
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DOI：
10.1177/2041731416648810
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发表时间：
2016-01
影响因子：
8.2
通讯作者：
Cao X
中科院分区：
文献类型：
--
作者：
Dai Z;Ronholm J;Tian Y;Sethi B;Cao X
生物可降解支架由于其在生物材料和组织工程中的广泛应用而得到广泛的研究。然而，与这些支架的体内使用相关的不同微生物污染物的感染仍然是一个重大的挑战。本文综述了不同的灭菌技术，包括热，化学，辐射，和其他新的灭菌技术，各种生物降解支架。这些技术的比较，包括它们的灭菌机制，灭菌后的效果，和灭菌效率，进行了讨论。
Biodegradable scaffolds have been extensively studied due to their wide applications in biomaterials and tissue engineering. However, infections associated with in vivo use of these scaffolds by different microbiological contaminants remain to be a significant challenge. This review focuses on different sterilization techniques including heat, chemical, irradiation, and other novel sterilization techniques for various biodegradable scaffolds. Comparisons of these techniques, including their sterilization mechanisms, post-sterilization effects, and sterilization efficiencies, are discussed.