Intentional and non-intentional non-adherence to medication amongst breast cancer patients
Intentional and non-intentional non-adherence to medication amongst breast cancer patients
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DOI：
10.1016/j.ejca.2006.03.004
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发表时间：
2006-09-01
影响因子：
8.4
通讯作者：
Fallowfield, Lesley
中科院分区：
文献类型：
--
作者：
Atkins, Louise;Fallowfield, Lesley
这项研究旨在调查乳腺癌患者样本中不坚持药物治疗的患病率及其相关因素。对131名病情稳定的妇女进行了访谈，完成了标准化的心理测量。55%的女性报告经常或偶尔不坚持服药，年轻女性和不喜欢服药的女性服药依从性明显降低(P=0.015，P=0.001)。故意不偶尔或频繁服用药片的女性在健康控制源的“内部”和“强大的他人”维度上的得分显著较低，表明影响较弱(P=0.032，P=0.009)。尽管有危及生命的诊断，但患者可能不会坚持药物治疗，这可能会错失获得健康的机会和浪费资源。此外，如果没有依从性信息，对临床试验数据的解释可能会产生误导。需要更多的研究来确定那些不遵守的风险。如果有其他给药途径，应与患者讨论这些选择，以最大限度地提高治疗效果。(C)2006爱思唯尔有限公司。保留所有权利。
This study aimed to investigate the prevalence of and factors associated with non-adherence to medication amongst a sample of breast cancer patients. 131 women with stable disease were interviewed and completed standardised psychological measures. 55% of women reported non-adherence to medication frequently or occasionally, with younger women and those who disliked taking their medication being significantly less adherent (P = 0.015, P = 0.001). Women who deliberately omitted taking their tablets occasionally or frequently had significantly lower scores, indicative of a weaker influence, on 'internal' and 'powerful others' dimensions of health locus of control (P = 0.032, P = 0.009). Despite a life-threatening diagnosis, patients may not adhere to medication representing a potential missed opportunity for health gain and waste of resources. Furthermore, interpretation of clinical trial data may be misleading without adherence information. More research is needed to identify those at risk for non-adherence. If other routes of administration are available these options should be discussed with patients to maximise efficacy of therapy. (c) 2006 Elsevier Ltd. All rights reserved.