Single-nucleotide polymorphisms in genes encoding for CC chemokines were not associated with the risk of non-Hodgkin lymphoma.
Single-nucleotide polymorphisms in genes encoding for CC chemokines were not associated with the risk of non-Hodgkin lymphoma.
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DOI：
10.1158/1055-9965.epi-13-0328
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Chen Q;Zheng T;Lan Q;Lerro C;Zhao N;Qin Q;Hu X;Huang H;Liang J;Holford T;Leaderer B;Boyle P;Chanock SJ;Rothman N;Zhang Y
趋化因子在免疫调节和反应中发挥着关键作用，先前的研究表明免疫缺陷与非霍奇金淋巴瘤(NHL)之间存在关联。我们利用在康涅狄格州进行的一项基于人群的病例对照研究数据，评估了编码CC趋化因子的18个基因(CCL1、CCL2、CCL5、CCL7、CCL8、CCL11、CCL13、CCL18、CCL20、CCL24、CCL26、CCR1、CCR3、CCR4、CCR6、CCR7、CCR8和CCR9)与NHL的相关性。CCR8与弥漫性大B细胞淋巴瘤相关(P=0.012)，CCL13与慢性淋巴细胞白血病或小淋巴细胞性淋巴瘤在基因水平上相关(P=0.003)。在调整多重比较后，没有一个基因或SNP与总体NHL或NHL亚型的风险相关。我们的结果表明，编码CC趋化因子的基因与NHL的风险没有显著相关性，还需要进一步的研究来验证这些发现。我们的数据表明CC趋化因子基因与NHL风险无关。
Chemokines play a pivotal role in immune regulation and response, and previous studies suggest an association between immune deficiency and Non-Hodgkin lymphoma (NHL). We evaluated the association between NHL and polymorphisms in 18 genes (CCL1, CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL18, CCL20, CCL24, CCL26, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8 and CCR9) encoding for the CC chemokines using data from a population-based case-control study of NHL conducted in Connecticut women. CCR8 was associated with diffuse large B-cell lymphoma (DLBCL) (p = 0.012) and CCL13 was associated with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) (p = 0.003) at gene level. After adjustment for multiple comparisons, none of the genes or SNPs were associated with risk of overall NHL or NHL subtypes. Our results suggest that the genes encoding for CC chemokines are not significantly associated with the risk of NHL, and further studies are needed to verify these findings. Our data indicate that CC chemokine genes were not associated with NHL risk.