Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration.

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration.
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干细胞稳态和骨组织再生中的蛋白聚糖和糖胺聚糖

DOI:
10.3389/fcell.2021.760532
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发表时间:
2021
影响因子:
5.5
通讯作者:
Wu J
Wu J
中科院分区:
生物学2区
文献类型:
--
作者:
Chen J;Sun T;You Y;Wu B;Wang X;Wu J

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干细胞在细胞内和细胞外成分共同支持的调控网络下,维持着自我更新和分化之间的微妙平衡。蛋白聚糖是大量存在于细胞表面和细胞外基质中的大的糖蛋白,它们在促进信号转导和维持干细胞稳态中起关键作用。本文综述了蛋白多糖的特性及其在干细胞稳态调节中的作用,以及蛋白多糖/糖胺聚糖作为新型糖组学载体或生物活性分子在骨再生中的研究进展和前景。
Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.
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