Synchrotron X-ray study at Trieste: No correlation between breast cancer and hair structure
Synchrotron X-ray study at Trieste: No correlation between breast cancer and hair structure
复制标题
的里雅斯特同步加速器 X 射线研究：乳腺癌与头发结构之间没有相关性
DOI：
10.1080/08940889908261033
复制
发表时间：
1999
影响因子：
--
通讯作者：
L. Palma
中科院分区：
文献类型：
--
作者：
H. Amenitsch;M. Rappolt;P. Laggner;S. Bernstorff;R. Moslinger;E. Fleischmann;T. Wagner;S. Lax;E. Petru;K. Hudabiunigg;L. Palma
结果结果总结见图2。在来自有BRCA-1和/或-2突变史的家族的所有病例中，即在BRCA突变携带者中的乳腺癌和/或卵巢癌（AC=受影响的携带者），在携带其中一种突变但没有癌症的人中（C=携带者）和阴性对照，无BRCA突变且无癌症，但与携带者有家族关系（NC：=非载体），我们发现了两种类型的X射线衍射图：有和没有4.4 nm环（图1）。在这三组中的任何一组中都没有环形模式的流行（图2A）。与此相反，AC-子群，根据工作由詹姆斯等人。[2]应该只显示出环状的图案，实际上显示出这种类型的比例最小。我们没有将任何统计学意义归因于C亚组中环状模式比例最高的事实，但重要的是要强调它总是低于50%。非携带者（NC）作为内部控制在这个家庭相关的人口，并显示出约30%的平均比例环模式。此外，还筛选了来自的里雅斯特的一小组乳腺肿瘤患者。同样，在良性肿瘤患者与“正常”毛发模式或乳腺癌患者与“改变”毛发模式之间也没有发现相关性。此外，即使是来自看似健康的男性捐赠者的毛发也显示出与看似健康的女性相似的分布（图2B），男性毛发样本中环状图案出现频率更高的趋势。
ResultsThe results are summarized in Figure 2. In all cases from families with a history of BRCA-1 and/or-2 mutations, ie, in carriers of a BRCA mutation with breast and/or ovary cancer (AC= affected carrier), in those who carry one of the mutations, but without cancer (C= carrier) and in negative controls without BRCA mutations and without cancer, but familially related to carriers (NC:= non-carrier), we found both types of X-ray diffraction patterns: with and without the 4.4 nm ring (Figure 1). There is no prevalence of ring-patterns in any of these three groups (Figure 2A). To the contrary, the AC-subgroup, which according to the work by James et al.[2] should show only the ring-type pattern, showed in fact the smallest proportion of this type. We do not attribute any statistical significance to the fact that the proportion of ring-patterns was found highest in the C-subgroup, but it is important to stress that it was always below 50%. The noncarriers (NC) served as an internal control within this familially related population, and showed the average proportion of about 30% ring patterns. Moreover, a small set of breast-tumor patients from Trieste was also screened. Here also, no correlation between patients with benign tumors with “normal” hair pattern or those with breast cancer and “changed” pattern, respectively, could be found. Furthermore, even hair from apparently healthy male donors showed a similar distribution to that from apparently healthy females (Figure 2B), with a tendency for the ring pattern to occur more frequently with hair samples from males.