Immunologic studies of the acquired immune deficiency syndrome: relationship of immunodeficiency to extent of disease.
Immunologic studies of the acquired immune deficiency syndrome: relationship of immunodeficiency to extent of disease.
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获得性免疫缺陷综合征的免疫学研究：免疫缺陷与疾病程度的关系。
DOI：
10.1111/j.1749-6632.1984.tb37156.x
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发表时间：
1984
影响因子：
5.2
通讯作者：
Newell,GR
中科院分区：
文献类型：
--
作者：
Hersh,EM;Reuben,JM;Mansell,PW;Rios,A;Gutterman,JU;Munn,G;Murray,JL;Spector,SP;Goldstein,AL;Newell,GR
对135例未经治疗的受试者进行了免疫学和常规实验室检查，其中28例(20.7%)为无症状同性恋者，74例(54.8%)为ARC患者，33例(24.5%)为艾滋病患者。半数以上患者淋巴细胞百分率、T_3~+细胞百分率、T_4~+细胞百分率和绝对数、T_8~+细胞百分率、T_4/T_8比值、单核细胞黏附率和血清胸腺素α_1均异常。淋巴细胞5‘核苷酸酶低会增加抑制性细胞的活性，IL-2和α干扰素的产生和反应受损表明成熟的和未成熟的外周血液和组织T细胞减少和增加。这些发现为艾滋病的分期、预测和治疗提供了方法。
Immunologic and conventional laboratory studies were done in 135 previously untreated subjects including 28 (20.7%) symptom-free homosexuals and 74 (54.8%) with ARC and 33 (24.5%) with AIDS. More than half of all patients had abnormal percentages of lymphocytes, percentages of T3+ cells, percentage and absolute number of T4+ cells, percentage of T8+ cells, T4/T8 ratio, monocyte adherence, and serum thymosin alpha 1. Most immune variables worsened with progressive disease. Low lymphocyte 5'nucleotidase increased suppressor cell activity, and impaired IL-2 and alpha interferon production and response suggest diminished mature and increased immature peripheral blood and tissue T cells. These findings suggest approaches to staging, prognostication, and treatment for AIDS.