Host-Microbe Metagenomics: a Lens To Refocus Our Perspective on Infectious and Inflammatory Diseases.
Host-Microbe Metagenomics: a Lens To Refocus Our Perspective on Infectious and Inflammatory Diseases.
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DOI：
10.1128/msystems.00404-21
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发表时间：
2021-08-31
期刊：
影响因子：
6.4
通讯作者：
Langelier CR
中科院分区：
文献类型：
--
作者：
Kalantar KL;Langelier CR
涉及病原体、宿主免疫应答和微生物组的动态关系表征了许多感染性和炎性疾病的生物学框架。组合宿主/微生物宏基因组学（mNGS）能够同时评估所有三个特征，从而能够研究和诊断从肺炎到败血症再到炎症性疾病（如类风湿性关节炎）的各种感染和炎症过程。宿主/微生物mNGS有望为新的机制见解，诊断方法和精准医学干预带来希望。
A dynamic relationship involving pathogen, host immune response, and microbiome characterizes the biological framework of many infectious and inflammatory diseases. Combined host/microbe metagenomics (mNGS) enables simultaneous assessment of all three features, enabling the study and diagnosis of diverse infectious and inflammatory processes ranging from pneumonia to sepsis to inflammatory diseases such as rheumatoid arthritis. Host/microbe mNGS holds promise for new mechanistic insights, diagnostic approaches, and precision medicine interventions.