Evidence of an autochthonous Toscana virus strain in Croatia
Evidence of an autochthonous Toscana virus strain in Croatia
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DOI：
10.1016/j.jcv.2012.06.006
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发表时间：
2012-09-01
影响因子：
8.8
通讯作者：
Avsic-Zupanc, Tatjana
中科院分区：
文献类型：
--
作者：
Punda-Polic, Volga;Mohar, Bojana;Avsic-Zupanc, Tatjana
目的：探讨托斯卡纳病毒在克罗地亚夏季无菌性脑膜炎中的作用。研究设计：对30例无菌性脑膜炎患者标本进行血清学和RT-PCR检测。结果：2/30例患者中检出TOSV RNA，4/30例患者中检出TOSV IgM抗体。L和S部分片段的系统发育分析表明，来自克罗地亚的TOSV代表了一种本土毒株。结论：本研究证实了TOSV是克罗地亚无菌性脑膜炎的病原体，因此医生在夏季遇到当地居民或旅行者的脑膜炎或发热性疾病时应予以考虑。(C)2012爱思唯尔B.V.保留所有权利。
Background: Phleboviruses are large and widespread group of viruses that are transmitted by arthropods and they have been reported to circulate in endemic regions of Mediterranean Basin, including Croatia.Objectives: To investigate the role of Toscana virus, as a cause of the aseptic meningitis, in summer months in Croatia.Study design: Samples from 30 patients with aseptic meningitis were retrospectively tested by serology and RT-PCR for TOSV.Results: TOSV RNA was detected in 2/30 and TOSV IgM antibodies were found in 4/30 of patients. Phylogenetic analysis of partial L and S segments suggests that TOSV from Croatia represents an autochthonous strain.Conclusions: The study has confirmed the role of TOSV as an agent that causes aseptic meningitis in Croatia, therefore it should be considered by physicians when encountering meningitis or febrile illness among indigenous population or travellers during the summer months. (C) 2012 Elsevier B. V. All rights reserved.