Endocannabinoid mechanisms of pain modulation
Endocannabinoid mechanisms of pain modulation
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DOI：
10.1208/aapsj080479
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发表时间：
2006-01-01
期刊：
影响因子：
4.5
通讯作者：
Suplita, Richard L., II
中科院分区：
文献类型：
--
作者：
Hohmann, Andrea G.;Suplita, Richard L., II
大麻素在急性、组织损伤和神经损伤诱导的伤害感受的动物模型中具有抗伤害感受性。本文综述了内源性大麻素（endocannabinoids）的生物学和行为，神经生理学和神经解剖学证据支持大麻素在疼痛调节中发挥作用的概念。行为药理学方法，结合通过使用液相色谱和气相色谱质谱法的内源性大麻素的鉴定和定量，提供了深入了解内源性大麻素在疼痛调制中的功能作用。在这里，我们研究大麻素受体和内源性大麻素水解酶的分布在疼痛调制电路与行为，神经化学和神经生理学的研究表明，内源性大麻素信号在疼痛调制的作用。本文就内源性大麻素2-花生四烯酸甘油和大麻素在应激镇痛中的作用作一综述。这些发现提供了一个功能框架，了解内源性大麻素的作用，在脊髓上的伤害性处理。
Cannabinoids are antinociceptive in animal models of acute, tissue injury-, and nerve injury-induced nociception. This review examines the biology of endogenous cannabinoids (endocannabinoids) and behavioral, neurophysiological, and neuroanatomical evidence supporting the notion that cannabinoids play a role in pain modulation. Behavioral pharmacological approaches, in conjunction with the identification and quantification of endocannabinoids through the use of liquid and gas chromatography mass spectrometry, have provided insight into the functional roles of endocannabinoids in pain modulation. Here we examine the distribution of cannabinoid receptors and endocannabinoid-hydrolyzing enzymes within pain modulatory circuits together with behavioral, neurochemical, and neurophysiological studies that suggest a role for endocannabinoid signaling in pain modulation. This review will provide a comprehensive evaluation of the roles of the endocannabinoids 2-arachidonoyl-glycerol and anandamide in stress-induced analgesia. These findings provide a functional framework with which to understand the roles of endocannabinoids in nociceptive processing at the supraspinal level.