Evaluation of prognostic factors for 233 patients with recurrent advanced breast cancer.
Evaluation of prognostic factors for 233 patients with recurrent advanced breast cancer.
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233例复发晚期乳腺癌患者的预后因素评估。
DOI：
10.1093/oxfordjournals.jjco.a039482
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发表时间：
1991
影响因子：
2.4
通讯作者：
T. Matsumura
中科院分区：
文献类型：
--
作者：
K. Inoue;M. Ogawa;N. Horikoshi;K. Aiba;T. Mukaiyama;N. Mizunuma;S. Itami;A. Hirano;A. Matsuoka;T. Matsumura
我们分析了233例主要接受阿霉素、环磷酰胺和福托萘啶（ACF）治疗和ACF改良的复发性晚期乳腺癌患者的可能预后因素。这些患者从1977年到1986年住在癌症研究所医院，随访到1989年。在化疗反应方面，31例（13%）患者完全缓解，100例（43%）患者部分缓解。化疗开始后的总中位生存期为20.3个月。评估的因素包括对化疗的反应、表现状态（PS）、年龄、无病间隔（DFI）、绝经期、转移部位数量（分级）、是否存在肝转移、是否存在恶性积液、是否存在既往放疗。在9个因素中，单因素分析显示化疗反应、PS、年龄、DFI和肝转移是影响生存率的显著因素，多因素分析显示化疗反应（P < 0.00001）、PS （P = 0.00001）和DFI （P < 0.00001）对生存率有显著影响。
We analyzed possible prognostic factors in 233 patients with recurrent advanced breast cancer treated primarily by adriamycin, cyclophosphamide and ftorafur (ACF) therapy and ACF modifications. The patients were in the Cancer Institute Hospital from 1977 to 1986, and were followed-up until 1989. In terms of chemotherapeutic response, complete and partial responses were observed in 31 (13%) and 100 (43%) patients, respectively. The overall median survival from the beginning of chemotherapy was 20.3 months. The factors evaluated were response to chemotherapy, performance status (PS), age, disease-free interval (DFI), menopausal status, number of metastatic sites (step classification), presence or absence of liver metastasis, presence or absence of malignant effusion, and presence or absence of prior radiotherapy. Out of the nine factors, response to chemotherapy, PS, age, DFI and liver metastasis were significant factors affecting survival in univariate analysis, and multivariate analysis of these five factors revealed the survival to be markedly affected by response to chemotherapy (P less than 0.00001), PS (P = 0.00001) and DFI (P less than 0.00001).