Developmental and environmental origins of breast cancer: DDT as a case study
Developmental and environmental origins of breast cancer: DDT as a case study
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DOI：
10.1016/j.reprotox.2010.10.004
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发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Cohn, Barbara A.
中科院分区：
文献类型：
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作者：
Cohn, Barbara A.
20多项关于血清“滴滴涕”和乳腺癌的研究发现，几乎没有证据支持接触滴滴涕会影响乳腺癌风险的假设。然而，这些研究都有一些共同的局限性，包括无法说明婴儿早期的接触情况，而此时乳房可能是最脆弱的，以及无法测量商用滴滴涕主要成分的接触情况。本文件（1）总结了关于乳腺癌关键接触窗口的证据（2）总结了从最初研究滴滴涕和乳腺癌的工作中吸取的经验教训（3）审查了儿童健康和发育研究（CHDS）的证据，其中使用在主动接触期间获得的血液样本测量了年轻妇女的接触情况，1-3天后交付和（4）建议的方法，为人类研究，可能会推进理解的环境压力因素的发展起源的疾病。(C)2010年爱思唯尔公司All rights reserved.
More than 20 studies of serum "DDT' and breast cancer have found little support for the hypothesis that exposure influences risk of breast cancer. However, studies share common limitations including the inability to account for exposure in early life when the breast may be most vulnerable and the inability to measure exposure to the primary components of commercial DDT. This paper (1) summarizes evidence regarding critical windows of exposure for breast cancer (2) summarizes lessons learned from initial efforts to study DDT and breast cancer (3) reviews evidence from the Child Health and Development Studies (CHDS) where exposure was measured in young women using blood samples obtained during active exposure, 1-3 days after delivery and (4) suggests approaches for human studies that might advance understanding of environmental stressors in the developmental origins of disease. (C) 2010 Elsevier Inc. All rights reserved.