Control of dendritic branching and tiling by the tricornered-kinase/furry signaling pathway in Drosophila sensory neurons
Control of dendritic branching and tiling by the tricornered-kinase/furry signaling pathway in Drosophila sensory neurons
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DOI：
10.1016/j.cell.2004.09.036
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发表时间：
2004-10-15
期刊：
影响因子：
64.5
通讯作者：
Jan, YN
中科院分区：
文献类型：
--
作者：
Emoto, K;He, Y;Jan, YN
为了完全覆盖感受野，但没有冗余，某些功能组的神经元通过树突排斥表现出其树突的平铺。在这里，我们表明，两个进化上保守的蛋白质，三角（Trc）激酶和毛茸茸的（弗莱），是必不可少的瓷砖和分支控制果蝇感觉神经元树突。fry和trc突变体的树突末端分支过多，不能避免同源树突分支，导致树突区域明显重叠。Trc对树突状分支的控制涉及RacGTdR的调节，这是一种与Trc在平铺中的作用不同的途径。延时分析进一步揭示了一个特定的损失的能力，越来越多的树突，从附近的树枝状分支在鱼苗突变体，暗示的缺陷，像排斥一样的避免。因此，Trc/ Fry信号通路通过促进同源树突之间的回避以及通过限制树突分支在图案化树突领域中起关键作用。
To cover the receptive field completely but without redundancy, neurons of certain functional groups exhibit tiling of their dendrites via dendritic repulsion. Here we show that two evolutionarily conserved proteins, the Tricornered (Trc) kinase and Furry (Fry), are essential for tiling and branching control of Drosophila sensory neuron dendrites. Dendrites of fry and trc mutants display excessive terminal branching and fail to avoid homologous dendritic branches, resulting in significant overlap of the dendritic fields. Trc control of dendritic branching involves regulation of RacGTPase, a pathway distinct from the action of Trc in tiling. Time-lapse analysis further reveals a specific loss of the ability of growing dendrites to turn away from nearby dendritic branches in fry mutants, suggestive of a defect in like-repels-like avoidance. Thus, the Trc/ Fry signaling pathway plays a key role in patterning dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching.