Components of both major axial patterning systems of the Bilateria are differentially expressed along the primary axis of a 'radiate' animal, the anthozoan cnidarian Acropora millepora
Components of both major axial patterning systems of the Bilateria are differentially expressed along the primary axis of a 'radiate' animal, the anthozoan cnidarian Acropora millepora
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DOI：
10.1016/j.ydbio.2006.07.034
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发表时间：
2006-10-15
影响因子：
2.7
通讯作者：
Miller, David J.
中科院分区：
文献类型：
--
作者：
de Jong, Danielle M.;Hislop, Nikki R.;Miller, David J.
刺胞动物是具有单一（口/背口）明显体轴的动物，其起源在名义上早于双侧性。为了更好地了解轴向图案化机制的演变，我们的特点是基因的珊瑚，鹿角珊瑚（类珊瑚虫）被认为是明确的标记的两侧前/后和背/腹轴。同源的OTx/otd和Emx/ems，确定的前标志物在两侧，在鹿角珊瑚幼虫的两端表达; otxA-Am最初围绕囊胚孔，后来优先向口端的外胚层，和emx-Am主要在推定的神经元中的aboral一半的浮游幼虫，在一个域重叠的cnox-2Am，GSH/ind基因。Pax-3/7，NKX2.1/vnd和Msx/msh的鹿角珊瑚同源物在幼虫外胚层中以轴向限制和很大程度上不重叠的模式表达。因此，在鹿角珊瑚中，双侧动物的D/V和A/P图案化系统的组成部分以区域限制的图案沿着浮浪幼虫的单个明显的身体轴表达，并且两个“前”标记在轴的相对端表达。因此，虽然一些特定的基因功能似乎是保守的刺胞动物和高等动物之间，没有简单的关系存在于两组的轴向图案系统。皇冠版权所有（c）2006由爱思唯尔公司出版。All rights reserved.
Cnidarians are animals with a single (oral/aboral) overt body axis and with origins that nominally predate bilaterality. To better understand the evolution of axial patterning mechanisms, we characterized genes from the coral, Acropora millepora (Class Anthozoa) that are considered to be unambiguous markers of the bilaterian anterior/posterior and dorsal/ventral axes. Homologs of Otx/otd and Emx/ems, definitive anterior markers across the Bilateria, are expressed at opposite ends of the Acropora larva; otxA-Am initially around the blastopore and later preferentially toward the oral end in the ectoderm, and emx-Am predominantly in putative neurons in the aboral half of the planula larva, in a domain overlapping that of cnox-2Am, a Gsh/ind gene. The Acropora homologs of Pax-3/7, NKX2.1/vnd and Msx/msh are expressed in axially restricted and largely non-overlapping patterns in larval ectoderm. In Acropora, components of both the D/V and A/P patterning systems of bilateral animals are therefore expressed in regionally restricted patterns along the single overt body axis of the planula larva, and two 'anterior' markers are expressed at opposite ends of the axis. Thus, although some specific gene functions appear to be conserved between cnidarians and higher animals, no simple relationship exists between axial patterning systems in the two groups. Crown Copyright (c) 2006 Published by Elsevier Inc. All rights reserved.