UTILIZATION OF ETHANOL .2. ALCOHOL-ACETALDEHYDE DEHYDROGENASE SYSTEMS IN LIVERS OF ALCOHOL-TREATED RATS
UTILIZATION OF ETHANOL .2. ALCOHOL-ACETALDEHYDE DEHYDROGENASE SYSTEMS IN LIVERS OF ALCOHOL-TREATED RATS
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DOI：
10.1093/jn/80.2.196
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发表时间：
1963-01-01
影响因子：
4.2
通讯作者：
DANIELSKI, J
中科院分区：
文献类型：
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作者：
DAJANI, RM;ORTEN, JM;DANIELSKI, J
在为期40周的观察期间，每隔2- 4周对对照大鼠和以20%乙醇溶液为唯一饮用液体的治疗大鼠肝脏中的酒精脱氢酶（ADH）和乙醛脱氢酶（ACDH）水平进行测定。两组均饲喂足够的纯化饲料。同时测定了部分对照组大鼠和乙醇处理大鼠以及部分正常人和酗酒者血清中ADH的水平。乙醇处理大鼠肝脏ADH水平逐渐高于对照组，在乙醇消耗26周后达到最大值。然后逐渐向控制值下降，这可能与治疗大鼠脂肪肝的发展有关。在给药20周后停止使用乙醇，ADH水平也同样下降到控制值。在乙醇处理的大鼠血清中ADH水平也有类似但不太明显的变化。与对照组相比，人类酗酒者血清ADH可检测到但变化性升高。乙醇处理大鼠肝脏中ACDH的活性先升高，后逐渐降低至控制水平，与ADH相似，但幅度较小。
The levels of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ACDH) were determined at 2- to 4-week intervals in the livers of control rats and of treated rats given a 20% solution of ethanol as the sole drinking fluid during a 40-week period of observation. Both groups were fed an adequate purified diet. The levels of ADH in blood sera were also determined in some of the control and ethanol-treated rats, and some normal and alcoholic human subjects. The hepatic level of ADH in the ethanol-treated rats progressively increased above control values to a maximum after 26 weeks of ethanol consumption. A gradual decrease toward control values then occurred, perhaps associated with the development of fatty livers in the treated rats. The withdrawal of ethanol after 20 weeks of administration likewise was followed by a decrease in ADH levels to control values. Parallel, but less distinct changes were noted in the ADH levels of the sera of ethanol-treated rats. Detectable, but variable elevations in serum ADH were similarly observed in human alcoholics as compared with control subjects. The activity of ACDH in the livers of the ethanol-treated rats showed an increase followed by a gradual decrease to control levels similar to that observed for ADH but was a lesser magnitude.