Reproductive toxicity of metals: critical time of prenatal exposure
Reproductive toxicity of metals: critical time of prenatal exposure
复制标题
金属的生殖毒性：产前暴露的关键时间
DOI：
10.1136/oemed-2018-icohabstracts.1445
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发表时间：
2018
影响因子：
4.9
通讯作者：
Ohtani K
中科院分区：
文献类型：
--
作者：
Vigeh M;Yokoyama K;Matsukawa T;Ohtani K
怀孕是女性生命中的一个独特时期，对有毒物质（如重金属）的敏感性增加。最近，暴露于潜在的有毒金属急剧下降，在一般人群和工人，但长期暴露于低水平仍然是一个公共卫生问题。MethodsWe进行了纵向研究，以估计产前金属暴露对各种妊娠结局的影响。使用ICP-MS装置采集母体全血（在妊娠的第一、第二和第三个三个月采集）和脐带血样品用于血液金属测量。我们使用结构式问卷收集参与者的特征信息和过去的生殖和医疗史。有关各种妊娠结局的数据收集在怀孕期间，并在deliver. ResultsWe发现血液金属在怀孕的早期阶段有更显着的影响妊娠结局，如低出生体重，早产，早产胎膜破裂，妊娠高血压比随后的三个月，或在脐带血。此外，本研究还揭示了高比率的金属通过胎盘，这可能会增加金属水平的两倍以上的胎儿网站比maternalblood.DiscussionThe早期妊娠金属暴露可诱发几个不良妊娠结局。因此，对高水平接触的女工，应在孕前或尽早考虑进行接触防护或筛查方案，因为后期干预可能无法预防不良反应。
IntroductionPregnancy is a unique period of women life with an increased sensitivity to toxicants, such as heavy metals. Recently, exposure to potentially toxic metals decreased sharply in both general population and workers but, chronic exposure to low-levels remained a public health problems.MethodsWe have conducted longitudinal studies to estimate effects of prenatal metal exposure on various pregnancy outcomes. Maternal whole blood (taken in the first, second, and third trimester of pregnancy) and umbilical cord blood samples were collected for blood metals measurement using ICP-MS devices. We collected participants’ characteristics information and past reproductive and medical history using a structured questionnaire. Data about various pregnancy outcomes gathered during pregnancy and at the delivery.ResultWe found blood metals at the early stage of pregnancy had more significant effects on pregnancy outcomes, such as low birth weight, preterm labour, preterm rupture of the membranes, and pregnancy induced-hypertension than the subsequence trimesters, or in the umbilical cord blood. In addition, the study revealed a high rate passing metals from placenta, which could increase metals level up to twice in fetal site than the maternal blood.DiscussionThe early gestation metal exposure can be induce several adverse pregnancy outcomes. Therefore, the exposure protection or screening programs for the high-level exposure female workers, should be considered before pregnancy or as early as possible, because later intervention may not prevent adverse effects.