ESTIMATING THE LOCATIONS AND THE SIZES OF THE EFFECTS OF QUANTITATIVE TRAIT LOCI USING FLANKING MARKERS
ESTIMATING THE LOCATIONS AND THE SIZES OF THE EFFECTS OF QUANTITATIVE TRAIT LOCI USING FLANKING MARKERS
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DOI：
10.1007/bf00222330
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发表时间：
1992-12-01
影响因子：
5.4
通讯作者：
CURNOW, RN
中科院分区：
文献类型：
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作者：
MARTINEZ, O;CURNOW, RN
利用侧翼标记的信息来估计位于两个标记之间的数量性状基因座(QTL)的效应的位置和大小被证明受到位于染色体相邻区域的QTL的影响。在某些情况下，位于侧翼区域之外的两个QTL的作用会被强化，以至于可能会错误地将一个“幽灵”QTL识别为真正的QTL。这些问题是在回交的框架内讨论的，使用回归模型作为分析工具来呈现理论结果。使用从三个或三个以上邻近标记获得的信息的回归模型被证明在分离邻近地区的QTL效应方面是有用的。一个模拟的数据集举例说明了这个问题，并通过区间映射法和回归模型进行了分析。
The use of information from flanking markers to estimate the position and size of the effect of a quantitative trait locus (QTL) lying between two markers is shown to be affected by QTLs lying in neighbouring regions of the chromosome. In some situations the effects of two QTLs lying outside the flanked region are reinforced in such a way that a 'ghost' QTL may be mistakenly identified as a real QTL. These problems are discussed in the framework of a backcross using a regression model as the analytical tool to present the theoretical results. Regression models that use information obtained from three or more nearby markers are shown to be useful in separating the effects of QTLs in neighbouring regions. A simulated data set exemplifies the problem and is analysed by the interval mapping method as well as by the regression model.